Probing Molecular and Surface Interactions of Mussel Adhesive Proteins by Using Surface Forces Apparatus，第六届亚欧研讨会上处理和性能增强聚合物会议文集（2013.6.2-6 武汉）-中国聚合物网,论文下载

Probing Molecular and Surface Interactions of Mussel Adhesive Proteins by Using Surface Forces Apparatus

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molecular interactions surface forces apparatus mussel adhesive
proteins

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111K

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分子表征

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第六届亚欧研讨会上处理和性能增强聚合物会议文集（2013.6.2-6 武汉）

简介：

Musselssurviveinturbulentseabyrobustunderwateradhesiontoallkindsofwaveandwind-sweptsubstrata,aswellashighlystiffandhighlyextensiblesurfacecoatingsusingaproteinaceousbyssus.Suchremarkablefeaturesmakethebyssusasourceofinspirationforthedevelopmentofnoveladhesives,coatingsandbiomaterialswhichcanbeintroducedinasimilarlyturbulentaqueousenwronmentinthehumanbody.Themusselbyssusresemblesabundleofthreadstippedwithadhesiveplaquesandcontainsroughly25-30differentproteins.Understandingtheadhesionandcohesionmechanismoftheseproteinsisofbothfundamentalandpracticalimportanceinthedevelopmentofbiomedicaladhesivesandcoatings.Ourgrouphasendeavoredtoinvestigatethemolecularandsurfaceinteractionmechanismsofmusseladhesiveproteinsbyapplyingamolecularforceprobetechnique-SurfaceForcesApparatus(SFA).TheSFAstudieswereperformedinvariousconfigurations:(i)aproteinfilmagainstdifferentsubstrata,(ii)aproteinfilmagainstanothersurfaceofthesameordifferentprotein,and(iii)proteinsolutionsconfinedbetweendifferentsubstrata.Itwasfoundthattheadhesionandcohesionofmusselfootproteinsarecriticallyrelatedtothemodifiedprominentaminoacid,L-3,4-dihydroxyphenylalanine(DOPA)orC2_mannosyl_7_hydroxytryptophan(Man70HTrp).Formusseladhesiontovarioussubstrata,DOPAplaystheimportantroleviadiverseinteractionsincludinghydrogenbonding,metalcoordination,cation-7rinteractions.DOPA-richproteinsmfp-3andmfp-5playamajorroleintheadhesionatplaque-substratainterfaces.DOPAalsocontributessignificantlytotheproteincohesionviametalcoordination(e.g.,DOPA_Ca2+,DOPA_Fe3+),cation-7rinteractions(e.g.,DOPA-Lys+).Ourresultsprovidenewinsightsintothedevelopmentofbiomimeticunderwateradhesivesandcoatingsforbiomedicalapplications.

作者：

Q. Y. Lu, H. B. Zeng

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2013-06-25 11:34:36

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