Microemulsion Supramolecular Gels for Protein Modulated Hydrophilic/Hydrophobic Dual-drug Delivery，第六届亚欧研讨会上处理和性能增强聚合物会议文集（2013.6.2-6 武汉）-中国聚合物网,论文下载

Microemulsion Supramolecular Gels for Protein Modulated Hydrophilic/Hydrophobic Dual-drug Delivery

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Microemulsion supramolecular gels Dual-drug delivery Protein modulated

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分子表征

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第六届亚欧研讨会上处理和性能增强聚合物会议文集（2013.6.2-6 武汉）

简介：

Mutil-drugdeliverysystemcanimprovetheefficiencyofthetreatmentofdiseases.Inthiswork,amicroemulsionsupramoleculargeI(MSG)wasdevelopedasdualdrugreleasedeliverysystem.Themicroemulsionconsistsofisopropylmyristate,Tween80,propyleneglycolandPBS;andl,3:2,4-di-O-benzylidene-D-sorbitol(DBS)wasusedforgelationthemicroemulsion.5-aminosalicylicacid(5-ASA)andcurcumin(Cur)wereemployedasdual-drugmodelfortheinvestigationofproteinmodulatedreleasebehaviorinthisdeliverysystem.DSCanddyesolubilitytestsshowedthatthepreparedmicroemulsionisbicontinuous;SEMimagesrevealedthatMSGhasathree-dimensionalnetwork.RheologicalmeasurementsrevealedthatMSGexhibitsawell-developednetworkandtheadditionofdualdrugexertsnoeffectonthetheologicalpropertiesofMSG.Theresultsindicatedthatthedualdrugreleasebehaviorcanbemodulatedbybovineserumalbumin(BSA).AtpH7.4,BSArestrainedthereleaseofdualdrug.WhenDBSconcentrationisl.5wt%,atpH7.4,thereleaseratesof5-ASAandCurdecreased14.46%and3%withthepresenceof0.5mg/mLBSArespectively.However,inacidicmedia(pHl.2)andweakacidicmedia(pH5.8andpH6.8),BSAcouldpromotethereleaseratesofdualdrug.AtpH5.8,thereleaseratesof5-ASAandCurincreased17.08%and7.62%withthepresenceofl.0mg/mLBSArespectively.TheseresultsrevealedthatMSGasaquicklyresponsetotheenvironmentstimulationdeliverysystemshaspotentialapplicationinmutil-drugrelease.

作者：

W. Li , Y. J. Yang, H. Wang

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2013-07-04 14:07:45

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