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Morphology of Poly (lactic acid) Scaffolds Fabricat by a Modified Solvent Casting/Porogen Leaching Method  
Morphology of Poly (lactic acid) Scaffolds Fabricat by a Modified Solvent Casting/Porogen Leaching Method
资料类型: PDF文件
关键词: morphology  porous  scaffold  porogen  leaching  poly(lactic  acid)  
资料大小: 112K
所属学科: 分子表征
来源: 第六届亚欧研讨会上处理和性能增强聚合物会议文集(2013.6.2-6 武汉)
简介:
Solventcasting/particulateleaching(SC/PL)ismostcommonlyusedforfabricatingmicro-porousandmacro-porouspolymerscaffolds.Theadvantageofthismethodisthattheprocessiseasytocarryoutandeasytocontroltheporesizeandporositybyselectingsuitableparticlesizeandamountoftheaddedsaltparticles.However,thescaffoldspreparedbythismethodusuallyhaveadensesurfacelayerandpoorinterconnectivitybetweenmacropores.Therefore,mostofthescaffoldspreparedbythismethodareeitherlimitedtotwo-dimensionalfilmsorconstructedbylaminationofseveralfilmsintodesiredshape.Inourpreviousstudy,amodifiedmethod,namelythesolventcasting/vacuumvolatilization/particulateleaching(SC/VV/PL)method,isproposedtofabricatethree-dimensionalpoly(lacticacid)(PLA)scaffoldscl]andgradedmacroporousPLAscaffoldc2]withadesiredrangeofcompressivemodulus,controlledporesizesandporosities.Inthisstudy,thePLAscaffoldswerefabricatedbytheSC/VV/PLmethodandtraditionalSC/PLmethodandwerecomparativelyresearched.Theeffectofthesizedistributionofporogenontheinterconnectivitybetweentheporeswasdiscussed,too.TheresultsshowedthattheSC/VV/PLmethodhassomeadvantageswhichcanovercomesomeshortcomingsofthetraditionalSC/PLmethod,suchasunsatisfactorysurfacestructure,longprocessingtimeandpoorinterconnectivitybetweenmacropores.Moreover,broadsizedistributionoftheporogenisbetterforforminggoodinterconnectivitybetweenmacropores.Whenthesmallsizeporogenwasblendedinthebigsizeporogen,thesmallNaCIparticlescanfilltheinterspaceamongthebigparticles.Thepackingvolumeoftheporogenwithbroadsizedistributionissmallerthanthesamequalityporogenwithnarrowsizedistribution.Thismeanstheporogenwithbroadsizedistributioncanbepackedmorecompactness.Thesmallparticlesbetweenbigparticlescancontributetowell-interconnectedporousstructure.
作者: X. H. Gong , L. Pan, X. Wang, J. Jiang, G. Zhang
上传时间: 2013-06-28 17:30:30
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