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Deoxycholic acid-grafted PEGylated chitosan micelles for the delivery of mitomycin C  
Deoxycholic acid-grafted PEGylated chitosan micelles for the delivery of mitomycin C
资料类型: PDF文件
关键词: Biodistribution  mitomycin  C  pharmacokinetics  polymeric  micelles  synthesis  
资料大小: 785k
所属学科: 通用高分子材料
来源: 来源网络
简介:
Mitomycin C (MTC) was incorporated to a micelle system preparing from a polymer named deoxycholic acid chitosan-grafted poly(ethylene glycol) methyl ether (mPEG-CS-DA). mPEG-CS-DA was synthesized and characterized by 1H nuclear magnetic resonance (1H-NMR)and Fourier transform infrared spectroscopy. mPEG-CS-DA formed a core-shell micellar structure with a critical micelle concentration of 6.57 mg/mL. The mPEG-CS-DA micelles werespherical with a hydrodynamic diameter of about 231 nm. After poly(ethylene glycol)ylation of deoxycholic acid chitosan (CS-DA), the encapsulation efficiency and drug loading efficiency increased from 50.62% to 56.42% and from 20.51% to 24.13%, respectively. The mPEG-CS-DA micelles possessed a higher drug release rate than the CS-DA micelles. For pharmacokinetics, the area under the curve (AUC) of the mPEG-CS-DA micelles was 1.5 times higher than that of MTC injection, and these micelles can enhance the bioavailability of MTC. mPEG-CS-DA micelles reduced the distribution of MTC in almost all normal tissues and had the potential to improve the kidney toxicity caused by MTC injection.
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上传时间: 2017-4-14 12:54:15
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