Crosslinking of poly(L-lactide) nanofibers with triallyl isocyanutrate by gamma-irradiation，ICAFPM 2011先进纤维与聚合物材料国际学术会议（2011.8.15~17，上海）-中国聚合物网,论文下载

Crosslinking of poly(L-lactide) nanofibers with triallyl isocyanutrate by gamma-irradiation

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poly (L-lactide) nanofibers crosslinking triallyl isocyanutrate gamma-irradiation

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ICAFPM 2011先进纤维与聚合物材料国际学术会议（2011.8.15~17，上海）

简介：

Poly(L-lactide)(PLLA)nanofiberhasattractedconsiderableattentionsduetoitspotentialapplicationasatissueengineeringscaffold,butitspoorthermalstabilityandmechanicalpropertiesrestrictitsapplications.Inthiswork,triallyisocyanurate(TAIC)wasaddedintoPLLAsolutionatdifferentratiosandfabricatedintonanofibrousmatsbyelectrospinningtechnique,thematswerethenirradiatedbygammarayatdifferentradiationdosestocrosslinkthePLLAchains.ThethermalpropertiesandbiodegradationpropertiesofdifferentPLLAsampleswereinvestigatedandcompared.Furthermore,theinvitrobiocompatibilitieswerealsoevaluatedbyusingmouseL929fibroblasts.Theresultsindicatedthatthethermalstabilityandtensilemechanicalpropertieswereincreasedaftercrosslinking,andthecrosslinkedsamplesirradiatedat10kGyexhibitedthebestenzymaticdegradation.TheinvitroresultsalsorevealedthatthecrosslinkedPLLA/TAICcompositenanofibersdidnotinducecytotoxiceffectsandsuitableforcellgrowth.Therefore,thecrosslinkedPLLAnanofibersareoneofthepromisingmaterialsforfuturetissueengineeringapplications.

作者：

HE Chuanglong, FENG Wei, CAO Lijun, FAN Lingpeng

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2011-09-28 14:04:55

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