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Nuclease-Functionalized Poly(Styrene?b?isobutylene?b?styrene) Surface with Anti-Infection and Tissue Integration Bifunctions  
Nuclease-Functionalized Poly(Styrene?b?isobutylene?b?styrene) Surface with Anti-Infection and Tissue Integration Bifunctions
资料类型: PDF文件
关键词: poly(styrene-b-isobutylene-b-styrene)  (SIBS)  deoxyribonuclease  (DNase)  ribonuclease  (RNase)  antibacterial  
cell  adhesion  
资料大小: 536k
所属学科: 功能高分子
来源: 来源网络
简介:
Hydrophobic thermoplastic elastomers, e.g., poly(styrene-b-isobutylene-b-styrene) (SIBS), have found various in vivo biomedical applications. It has long been recognized that biomaterials can be adversely affected by bacterial contamination and clinical infection. However, inhibiting bacterial colonization while simultaneously preserving or enhancing tissue-cell/material interactions is a great challenge. Herein, SIBS substrates were functionalized with nucleases under mild conditions, through polycarboxylategrafts as intermediate. It was demonstrated that the nucleasemodified SIBS could effectively prevent bacterial adhesion and biofilm formation. Cell adhesion assays confirmed that nuclease coatings generally had no negative effects on L929 cell adhesion, compared with the virgin SIBS reference. Therefore, the as-reported nuclease coating may present a promising approach to inhibit bacterial infection, while preserving tissue-cell integration on polymeric biomaterials.
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上传时间: 2014-10-22 16:32:29
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