Fabrication and Characterization of Nano-HAp Reinforced Poly-D-L-Iactide Scaffolds with Poly (ethylene glycol) /Dexamethasone Coatings，第六届亚欧研讨会上处理和性能增强聚合物会议文集（2013.6.2-6 武汉）-中国聚合物网,论文下载

Fabrication and Characterization of Nano-HAp Reinforced Poly-D-L-Iactide Scaffolds with Poly (ethylene glycol) /Dexamethasone Coatings

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关键词：

pdlla/nano-hap composites porous drug release shape memory
effect

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所属学科：

分子表征

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第六届亚欧研讨会上处理和性能增强聚合物会议文集（2013.6.2-6 武汉）

简介：

Multifunctionalscaffoldscl],whichhavecontrollablebiodegradability,drugdeliveryfunction,andshapememoryeffect,havebeenattractinggreatresearchinterestinthefieldofbonetissueengineeringrecently.Anoveltechniquecombiningwithpolymercoagulation,coldcompressionmoulding,saltparticulateleachingandadrugcoatingmethodhasbeendevelopedtofabricateporouspoly-D-L-lactide/nano-hydroxyapatite(PDLLA/nano-HAp)scaffoldswithpoly(ethyleneglycol)/dexamethasone(PEG/Dex)coatingsC2].Thescaffoldsfabricatedbythistechniquepossesshomogenousporenetworkswithindependentlycontrollableporosityandporesize.Fillingthematrixwithnano-HApparticlescanimprovethemechanicalpropertiesofthecompositescaffolds.ThesurfacehydrophilicityofthescaffoldwasfoundtobeimprovedbyaPEG/Dexcoatingandnano-HApaddition.AninvitrodrugreleasestudyofthePEG/DexcoatedPDLLA/nano-HApscaffoldshasshownthatthedrugreleasebehaviorofthescaffoldscanbeadjustedbyvaryingtheporositylevelandthefilledvolumefractionofthenano-HAp.Apatitecouldbeformedthecompositescaffoldwithnano-HApafterexposuretoasimulatedbodyfluid,leadingtoanimprovementinthebioactivityandapatiteformationabilityofthescaffold.Shapememorypropertiesofthescaffoldshavebeendemonstratedbyshaperecoveryandcyclicthermalmechanicaltests.Theresultsshowthattheshaperecoveryratioandshapefixityrateofthescaffoldsareinfluencedbytheporosity.Moreover,therecoverabilityofthecompositescaffoldsisalsoaffectedbythecontentofthenano-HAp.

作者：

L. Ched , C. Y. Tang, C. P. Tsui, D. Z. Chen

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2013-06-25 13:04:16

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