Polymer Blends and Composites for Biodegradable Coronary Stents and Tissue Scaffolds，第六届亚欧研讨会上处理和性能增强聚合物会议文集（2013.6.2-6 武汉）-中国聚合物网,论文下载

Polymer Blends and Composites for Biodegradable Coronary Stents and Tissue Scaffolds

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关键词：

biodegradable plla tissue scaffolds

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所属学科：

分子表征

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第六届亚欧研讨会上处理和性能增强聚合物会议文集（2013.6.2-6 武汉）

简介：

Inseveralbranchesofthemedicalfield,fromcardiologyorthopaedicstotissueengineering,therehasbeenanincreasingtrendintheuseofbiodegradablematerialsinplaceoftraditional,biostablematerials,suchasmetals,ceramicsandsyntheticpolymers.Biodegradablepolymersandtheircompositesareprominentintheseareasandareofgreatinterestforresearchbecausethereismuchroomforimprovement.Thispaperwillfocusontheapplicationofpolymerblendsandcompositesinbioabsorbablestentsandtissuescaffolds.PLLAisveryprominentinthefieldofbioabsorbablestentsbutitsuffersfrombrittlenesswhichmustbemitigated.OnemethodofdoingthisistoblendPLLAwithrubberypolymerstocreateductileblendswhichstrikeabalancebetweenductility,strength,modulusanddegradationcharacteristics.Thispaperdiscussesthedevelopmentoftheirmechanicalcharacteristics,fromYoung‘smodulustocreep,whichoccursduringdegradation.PLLAisalsoacommonmaterialunderinvestigationfortissuescaffolds.Alargeproportionofworkinthisareafocusesonelectrospinningtocreatetissuescaffoldsbutthisrequirestheuseoforganicsolvents.AprocessforproducingscaffoldswithouttheuseoforganicsolventshasbeendevelopedattheCentreforAdvancedCompositeMaterials,TheUniversityofAuckland.Theprocessinvolvesdrawingofanextrudedpolymercompositefilamenttofibrilisethedispersedphase.Afterproducinganetworkofmicro-/nano-fibrilsthroughacommonmanufacturingtechnique,thematrixisremovedviadissolutioninwater,leavinga3-Dfibrillar,nanoporousnetwork.Thisnetworkcanbeusedasatissuescaffoldwiththeadvantageoverelectrospunnetworksofhavingnoresidualorganicsolventcontent.Thispaperdescribestheprocessofscaffoldmanufacturingwithsomeresultsofin-vitrocellculture.

作者：

D. Bhattacharyya* , L. Kimble, S. Lin

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2013-06-21 11:39:18

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