Acyclovir-loaded PAN nanofiber membranes prepared using a special electrospinning process，2009先进纤维与聚合物材料国际学术会议（ICAFPM，10.21-10.24，上海）-中国聚合物网,论文下载

Acyclovir-loaded PAN nanofiber membranes prepared using a special electrospinning process

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Nanofiber membrane electrospinning process drug delivery elevated
temperature

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2009先进纤维与聚合物材料国际学术会议（ICAFPM，10.21-10.24，上海）

简介：

Aspecialelectrospinningprocesswassuccessfullydevelopedforthepreparationofacyclovir-loadedPANnanofibermembraneinthepresentstudy.Anadditionalapparatusforadjustingthetemperatureofthespinningsolutionswasfittedontheglasssyringeforeasyspinningandgettingbetterperformanceofnanofibers.PANnanofibersandacyclovir-loadedPANnanofiberswerepreparedusingthisprocesswithDMSOassolvent.Thesurfacetopographiesoftheas-preparednanofibermembraneswereobservedusingpolarizationopticalmicroscope.Theresultsdemonstratedthatthenanofibersweremoreuniformwithverysmoothsurfacewhentheelectrospinningprocesswascarriedoutat80°C.However,thenanofiberswereconglutinatedtogethertoformfibermatswithapoorstructurewhenelectrospinningwasconductedatanormalambienttemperature.Electrospinningat80°Cwasabletoformdrug-loadednanofiberswithuniformstructureandwelldrugdistribution,whereaselectrospinningat60°CresultedinaphaseseparationduetothepoorsolubilityofacyclovirinDMSOatalowertemperature.Risingelectrospinningtemperaturefacilitatesthepreparationofdrug-loadednanofibers.

作者：

YU Dengguang, ZHANG Xiaofei, WU Xiaomei, CHRIS BW, ZHU Li-Min

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2010-03-24 14:23:46

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