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Bio-distribution study of mixed-shell micelles with micro-phase separated surface  
Bio-distribution study of mixed-shell micelles with micro-phase separated surface
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资料大小: 173K
所属学科: 分子表征
来源: 第十届高分子物理国际研讨会(PP’2012)(2012.6.4~8,成都)
简介:
Wefacilelyfabricatedaseriesofmixed-shellmicelles(MSMs)underspontaneouslyself-assemblyofblockcopolymerspoly(ethyleneglycol)-b-poly(L-lysine)(PEG-b-PLys)andpoly(N-isopropylacrylamide)-b-poly(asparticacid)(PNIPAM-b-PAsp)inaqueousmedium.MSMswithgradientsurfacemicro-phaseseparationwereobtainedundertemperatureabovethelowercriticalsolutiontemperature(LCST)ofPNIPAMaftercorecrosslinking.Fourentitiesofsurfacephase-separatedMSMswithgradienthydrophilictity/hydrophobicity,ofwhichtheweightratioofPEGsegmenttoPNIPAMsegment(WPEG/WPNIPAM)were10/0,7/3,5/5,and3/7respectively(MSMs-0,MSMs-30,MSMs-50,andMSMs-70forshort),wereobtainedbythevariationoftherelativeamountofthetwoblockcopolymers.ComparedwithsolePEGylationmicelles,theMSMswithmicro-phaseseparatedsurfaceexhibitedhighlyimprovedbiologicalbehaviorsandrationalsurfacemicro-phaseseparationwereprovedtobesignificantlyefficientwithreducedaccumulationinliverandspleenandprolongedcirculationinblooddeterminedbythemethodofPositronEmissionTomography(PET)
作者: Hongjun Gao, Jie Xiong,Tangjian Cheng, Jinjian Liu,Liping Chu, Jianfeng Liu,Rujiang Ma,Yingli An, Linqi, Shi
上传时间: 2012-11-09 15:30:49
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