A new way to prepare core-shell biocompatible polymeric nano-particles from gelatin and acrylic acid

关键词：

nano-particles interpolymer complex

类别：

新产业 >> 医用材料

来源：

2005年新型纤维与聚合物材料国际学术会议（2005.10.19-21 上海）

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简介：

Core-shell biocompatible polymeric nano-particles were obtained in aqueous solution with insoluble interpolymer complex of gelatin and poly (acrylic acid)(PAA) as core and soluble gelatin as shell (denoted as gelatin/PAA nano-particles). We prepared narrowly distributed gelatin/PAA nano-particles at relatively higher concentration (30mg/mL) via in-situ polymerization of acrylic acid in the aqueous solution of biocompatible gelatin. Dynamic light scattering and electrophoretic light scattering techniques were used to trace the in-situ polymerization process. Glutaraldehyde was used as cross-linking reagent for gelatin to lock the structure of the particles. Furthermore, the pH responsive behaviors of gelatin/PAA nano-particles before and after cross-linking were studied.

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2007-07-31 16:04:02

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