writer：X. L. Jin, X. L. Wu, B. Wang, P. Xie, Y. L. He, H. W. Zhou,? B. Yan, J. J. Yang, W. X. Chen, X. H. Z
keywords：Fluorescein, Zinc ion, ATP ,Visualizing, Fluorescence
source：期刊
specific source：Sensors and Actuators B
Issue time：2018年

A reversible fluorescein-based fluorescent probe which exhibits high sensitivity and selectivity for Zn²⁺ and ATP, has been designed and synthesized. The sensing process was completed via fluorescence variation induced by an opening and closing of the spiro-ring of fluorescein. Zn²⁺/ATP-induced fluorescent intensity shows a good linear relationship with the concentration of Zn²⁺/ATP in the range of 0–10 M with a detection limit of 0.1 M/0.5 M. Moreover, the probe was further applied to visualize and detect Zn²⁺and ATP in vitro and in vivo.