writer：Jilan Wang,, Zihao Zhang, Ye Bi, Hongyan Ruan, Guoqing Sun, Xianping Cui, Xinlin Yang, and Chengkun
keywords：Nitric oxide, Targeting therapy, Tumor, Nanoparticle, Polymeric brushes.
source：期刊
specific source：J. Biomater. Sci., in press.
Issue time：2018年

A kind of tumor targeting nitric oxide donor nanoparticle with brushes is described in this paper. The poly(4-vinylphenylboronic acid) polymeric brush, which shows glucose and pH dual responsiveness, endows the hollow S-nitrosothiols nanoparticle the ability to accurate recognition and binding with the sialic acid over-expressed type tumor cells, such as HepG2 and MCF-7 cells. In vitro experiments, including cells capture and release experiments, confocal fluorescence microscope characterization, cytotoxicity assay with different cells, demonstrate the selective recognition and the controlled NO release for tumor cells killing ability. As the endogenous nature and the physiological necessity to regulate normal biological functions, low concentration of the released NO from the S-nitrosothiols nanoparticles in the transmission would participate physiological activity and avoid serious side effects. To the best of our knowledge, this is the first report about NO donor polymer nanoparticles with functional brushes to selectively identify tumor cells and release NO in a controlled manner.