Gene therapy is considered a highly effective treatment approach for many diseases. However, viral vectors used for gene delivery pose safety concerns and can trigger immune reactions. As a result, research on cationic polymer gene vectors, particularly supramolecular hyperbranched polycations, has gained significant attention in recent years. In comparison to linear cationic polymer gene vectors, covalent supramolecular hyperbranched polycations offer advantages in gene transfection efficiency. However, their toxicity increases with molecular weight. To address these challenges, our research group and collaborators have designed and synthesized a supramolecular hyperbranched polycation based on PGMA (Poly(glycidyl methacrylate)), which exhibits excellent biocompatibility and high gene transfection efficiency. This work provides a new approach for designing efficient supramolecular gene vectors.

  The related research work has been published online in the journal "Polymer Chemistry" (2016, DOI: 10.1039/C6PY00759G) and was selected as an Outside Cover article. The full article can be accessed at the following link: http://pubs.rsc.org/en/content/articlelanding/2016/py/c6py00759g#!divAbstract.

  The co-first authors of the paper are Qi Miao, a master''s student in our research group, and Dr. Shun Duan from Beijing University of Chemical Technology. The corresponding authors are Professor Wei Tian and Professor Fujian Xu from Beijing University of Chemical Technology. This work was supported by the National Natural Science Foundation of China (Grant No. 21374088) and the "New Century Excellent Talents" Program of the Ministry of Education of China (Project No. NCTE130476).

  该论文的共同第一作者为课题组硕士生亓淼和北京化工大学段顺博士，共同通讯作者为田威教授和北京化工大学徐福建教授。该工作得到了国家自然科学基金面上项目（基金号：21374088）和教育部“新世纪优秀人才”（项目号：NCTE130476）等项目的资助。