writer：Shijun Shao
keywords：nanofibers; electrospun;conductive;tissue engineering
source：期刊
specific source：Biomaterials,2011, 32, 2821-2833.
Issue time：2011年

The electrospinning process was utilized successfully to fabricate the random oriented and aligned electrically conductive nanofibers of biodegradable poly-DL-lactide (PLA) in which multiwalled carbon nanotubes (MWCNTs) were embedded. The topographical features of the composite nanofibers were characterized by SEM. The dispersion and alignment of MWCNTs in nanofiber matrix were observed by
TEM. The in vitro degradation was characterized in terms of the morphological change, the mass loss and the reduction of polymer molecular weight as well as the decrease of pH value of degradation media. In particular, these conductive nanofiber meshes offered a unique system to study the synergistic effect of
topographic cues and electrical stimulation on osteoblasts outgrowth as a way of exploring their potential application in bone tissue engineering.