writer：3) Wendong Liu, Yunfeng Li, Tieqiang Wang, Daowei Li, Liping Fang, Shoujun Zhu,Huaizhong Shen, Junhu
keywords：polymer brush, protein patterns, elliptical ring arrays, cell adhesion
source：期刊
specific source：ACS Appl. Mater. Interfaces 2013, 5, 12587?12593
Issue time：2013年

This paper presents a novel method to fabricate

elliptical ring arrays of proteins. The protein arrays are

prepared by covalently grafting proteins to the polymer brush

ring arrays which are prepared by the techniques combining

colloidal lithography dewetting and surface initiated atom-

transfer radical polymerization (SI-ATRP). Through this

method, the parameters of protein patterns, such as height,

wall thickness, periods, and distances between two elliptical

rings, can be ?nely regulated. In addition, the sample which

contains the elliptical protein ring arrays can be prepared over a large area up to 1 cm2, and the protein on the ring maintains its

biological activity. The as-prepared ring and elliptical ring arrays (ERAs) of ?bronectin can promote cell adhesion and may have

an active e?ect on the formation of the actin cytoskeleton.