作者：(30) Zheng, Y. L.; Zhong, L.; Huang, W.; Zhou, Y. F.*; Yan, D. Y.
关键字：dendritic heteroarm star copolymers, drug delivery systems, drug release, LCST, micelles, reversible addition-fragmentation chain transfer (RAFT), thermoresponsive
论文来源：期刊
具体来源：J. Polym. Sci., Part A: Polym. Chem. 2010, 48, 4428. http://onlinelibrary.wiley.com/doi/10.1002/pola
发表时间：2010年

In this article, we report the self-assembly of flocculation-resistant multimolecular micelles with thermoresponsive corona from novel dendritic heteroarm star copolymers. The micelles have a core-shell-corona structure at room temperature according to pyrene probe fluorescence spectrometry, proton nuclear magnetic resonance (¹H NMR), transmission electron microscopy, and dynamic light scattering measurements. Increasing the temperature above the lower critical solution temperature (LCST), the micelles show high flocculation-resistant ability resulting from a structure transition from core-shell-corona to core-shell confirmed by a quantitative variable temperature ¹H NMR analysis method using potassium hydrogen phthalate as an external standard. A big volume change of the micelles is observed during the LCST transition. The drug loading and temperature-dependent release properties of the micelles are also investigated by using coumarin 102 as a model drug, which displays a rapid drug release at a temperature above the LCST. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2010