writer：Xiaopeng Cheng, Honghui Shi, Zhaofei Wang, Guoqiang Zheng(通讯作者), Pingping Liu, Kun Dai, Chuntai Liu,
keywords：multilayered scaffolds, controllable architectures, large-scale, drug delivery, cell self-seeding
source：期刊
specific source：ACS Applied Materials and Interfaces, 2018, 10: 43512–43522
Issue time：2018年

Multilayered objects are the most important and interesting structures in nature, exhibiting multiple functionalities. Inspired by the excellent structural-functional characteristics of nature creatures, concentric-cylindrical multilayered scaffolds were prepared by a combination of melt

extrusion and leaching, in which well-defined alternating microlayer/gap is assembled. Furthermore, the macroscopic shape, internal structure and surface topography of such multilayered scaffold can be elaborately prepared by simple physical process. The whole process is low-cost, efficient and environmentally friendly. Furthermore, such multilayered scaffolds show some interesting applications, e.g., lipophilic/hydrophilic drugs delivery and cell self-seeding. Considering the facile preparation process and versatile applications, this study will open up a new pathway to fabricate scaffolds with controllable architectures and expand biodegradable polymer applications.