作者：Rujian Jiang, Yaozhen Yi, Lingwan Hao, Yuxiang Chen, Limei Tian, Haixu Dou, Jie Zhao*, Weihua Ming,
关键字：mechano-bactericidal, bacteria release, nanostructures, thermoresponsive, antibiotic resistance
论文来源：期刊
具体来源：ACS Applied Materials & Interfaces
发表时间：2021年
Overuse of antibiotics can increase the risk of notorious antibiotic resistance in bacteria, which has become a growing public health concern worldwide. Featured with the merit of mechanical rupture of bacterial cells, the bioinspired nanopillars are promising alternatives to antibiotics for combating bacterial infections while avoiding antibacterial resistance. However, the resident dead bacterial cells on nanopillars may greatly impair their bactericidal capability and ultimately impede their translational potential toward long-term applications. Here, we show that the functions of bactericidal nanopillars can be significantly broadenedby developing a hybrid thermoresponsive polymer@nanopillarstructured surface, which retains all of the attributes of pristine nanopillars and adds one more: releasing dead bacteria. We fabricate this surface through coaxially decorating mechano-bactericidal ZnO nanopillars with thermoresponsive poly(Nisopropylacrylamide) (PNIPAAm) brushes. Combining the benefits of ZnO nanopillars and PNIPAAm chains, the antibacterial performances can be controllably regulated between ultrarobust mechano-bactericidal action (～99%) and remarkable bacteriareleasing efficiency (～98%). Notably, both the mechanical sterilization against the live bacteria and the controllable release for the pinned dead bacteria solely stem from physical actions, stimulating the exploration of intelligent structure-based bactericidal surfaces with persistent antibacterial properties without the risk of triggering drug resistance