作者：Jing Sun, Lingjie Song, Yong Fan, Limei Tian, Shifang Luan, Shichao, Niu, Luquan Ren, Weihua Ming
关键字：antibacterial; nanocomposite membrane; photodynamic therapy; photothermal therapy; synergistic effects; upconversion nanoparticles
论文来源：期刊
发表时间：2019年
Herein, we developed a nanocomposite membrane with synergistic photodynamic therapy and photothermal therapy antibacterial effects, triggered by a single near-infrared (NIR) light illumination. First, upconversion nanoparticles (UCNPs) with a hierarchical structure (UCNPs@TiO 2 ) were synthesized, which use NaYF 4 :Yb,Tm nanorods as the core and TiO 2 nanoparticles as the outer shell. Then, nanosized graphene oxide (GO), as a photothermal agent, was doped into UCNPs@TiO 2 core-shell nanoparticles to obtain UCNPs@TiO 2 @GO. Afterward, the mixture of UCNPs@TiO 2 @GO in poly(vinylidene) fluoride (PVDF) was applied for electrospinning to generate the nanocomposite membrane (UTG-PVDF). Generation of reactive oxygen species (ROS) and changes of temperature triggered by NIR action were both investigated to evaluate the photodynamic and photothermal properties. Upon a single NIR light (980 nm) irradiation for 5 min, the nanocomposite membrane could simultaneously generate ROS and moderate temperature rise, triggering synergistic antibacterial effects against both Gram-positive and -negative bacteria, which are hard to be achieved by an individual photodynamic or photothermal nanocomposite membrane. Additionally, the as-prepared membrane can effectively restrain the inflammatory reaction and accelerate wound healing, thus exhibiting great potentials in treating infectious complications in wound healing progress.