相关链接
联系方式
  • 通信地址:天津市南开区卫津路94号,南开大学蒙民伟楼104室
  • 邮编:300071
  • 电话:022-23501645
  • 传真:
  • Email:zhangxinge@nankai.edu.cn
当前位置:> 首页 > 论文著作 > 正文
11. Synthesis and physicochemical characterization of a novel amphiphilic polylactic acid-hyperbranched polyglycerol conjugate for protein drug delivery.
作者:Xiujun Gao, Xinge Zhang*, Zhongming Wu, Xuejiao Zhang, Zhen Wang, Chaoxing Li*
关键字:hyperbranched polyglycerol
论文来源:期刊
具体来源:Journal of Controlled Release, 2009, 140:141-147.
发表时间:2009年

Amphiphilic copolymers with polylactic acid (PLA) chains grafted onto hyperbranched polyglycerol (HPG) have been synthesized and characterized. The copolymer nanoparticles with corona and core structure were formed by self-assembly in aqueous solution. The loading capacity and association efficiency were up to 23% and 86%, respectively. Protein release profiles with different copolymer compositions and BSA concentrations all showed a burst effect followed by a continuous release phase. The released BSA from the copolymer nanoparticles remained in its original structure over a period of 4 days, as testified by circular dichroism spectroscopy. Furthermore, cell viability research suggested good biocompatibility of the copolymer nanoparticles, which have a promising potential for protein delivery system.