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[Adv. Synth. Catal.] Copper-Nitrene Triggered Annulation of α-Acyl Cinnamides: Access to Isoxazol-3(2H)-ones
作者:[2] Yu, M.; Zhang, Q.; Li, G.; Yuan, J.; Zhang, N.*; Zhang, R.; Liang, Y.; Dong, D.*
关键字:Nitrene, Annulation
论文来源:期刊
具体来源:Adv. Syn. Cata.
发表时间:2016年
A facile and efficient one-pot synthesis of isoxazol-3(2H)-ones has been developed starting from α-acyl cinnamides and tosyliminophenyliodinane catalyzed by copper(II) acetate [Cu(OAc)2] under very mild conditions involving a tandem aza-Michael addition and intramolecular cyclization sequence.