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课题组工作在Organic Letters 上发表

摘要:

A domino reaction of readily available 1-carbamoyl-1-dimethylaminoalkenoylcyclopropanes in the presence of triflic anhydride (Tf2O) in N,N-dimethylformamide (DMF) is described, which provides a facile one-pot access to 2,3-dihydrofuro[3,2-c]pyridin-4(5H)-ones via tandem formylation (Vilsmeier-type reaction), intramolecular cyclization, and ring-enlargement sequences.