writer：Fenguo Zhou, Xu Liu, Ning Zhang *, Yongjiu Liang, Rui Zhang, Xiaoqing Xin, and Dewen Dong*
keywords：Solvent-Controlled, Regioselective, iminopyridines
source：期刊
Issue time：2013年

Regioselective synthesis of multisubstituted 4-amino- and 6-amino-2-iminopyridines has been developed via the copper-catalyzed three-component reaction based on the reaction conditions selection. The reaction of sulfonyl azides, alkynes, and 2-[(amino)methylene]malononitriles catalyzed by copper(I) iodide in tetrahydrofuran at room temperature afforded substituted 4-amino-2-iminopyridines, whereas, in N,N-dimethylformamide at 50 °C under N₂, it generated substituted 6-amino-2-iminopyridines as predominant products.