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[Synthesis] Efficient and Divergent Synthesis of Functionalized Cyclopropanes via Iodoform Reaction
writer:Dingyuan Zhang, Rui Zhang, Dexuan Xiang, Ning Zhang,* Yongjiu Liang, Dewen Dong*
keywords:cyclopropanes, iodoform reaction, iodine, amide
source:期刊
specific source:Synthesis
Issue time:2012年

Efficient and divergent one-pot synthesis of cyclopropyl amides and esters from readily available 1-acetylcyclopropanes via iodoform reaction based on reaction conditions selection is reported. A series of substituted cyclopropyl amides were synthesized from 1-acetyl-cyclopropanes in the presence of iodine and ammonia in water in good yields, whereas substituted cyclopropyl esters were obtained from the reaction of 1-acetylcyclopropanes with iodine and alcohols in the presence of DBU.