于明明，教授，硕士生导师。
1998年毕业于吉林大学。2005年5月于中科院理化所获博士学位。清华大学化学系博士后工作后，2007年到郑州大学工作。先后被评为校级青年骨干教师、省级青年骨干教师。2017年8月-2018年8月在美国新泽西理工学院进行访学研究。
主要从事生物荧光分子探针和荧光高分子的研究。任职以来主持国家自然科学基金两项，参与一项，在Org. Lett.、Chem. Commun.、Inorg. Chem.、Langmuir、Anal. Chem.、J. Mater.
Chem. C等杂志上发表论文四十余篇。2010年9月发表在Chem. Commun.的论文下载次数为当月该杂志的第三。2012年9月发表在New J. Chem.的文章为当月该杂志下载次数Top-Ten的第一。为Biosensors
and Bioelectronics、Sensors and Actuators B、Analytica
Chimica Acta、Dyes and Pigments等杂志的审稿人，2019年开始为“中国化学快报”青年编委。
联系方式
电子邮件：yumm@zzu.edu.cn
个人网址：https://www.x-mol.com/groups/yu_mingming
实验室：化学实验楼121
通讯地址：郑州大学化学与分子工程学院 450001
招生专业：物理化学（功能材料方向）
研究兴趣：
生物荧光探针
研究具有高灵敏性、快速响应、高空间分辨率的荧光小分子、纳米复合物和生物高分子探针，探讨探针的识别机制，用于生物体内一些重要生理过程生命相关的荧光成像。
荧光功能高分子材料
研究高分子的荧光响应、能量传递、生物模拟以及高分子结构与荧光相互作用的规律。这方面研究期望用于荧光离子捕获、荧光染料以及生物标记与药物输运领域。
主持的研究课题：
国家自然科学基金“羧酸酯酶的上转换复合纳米近红外比率发光探针的制备及其生物成像”（项目批准号：U1704161）
郑州大学化学与分子工程学院“青年学术骨干”教师基金
国家自然科学基金“具有双识别协同作用的锌、铜离子荧光分子探针”（项目批准号：50903075）
中国科学院光化学转换与功能材料重点实验室开放课题“人造捕光天线的分子设计与应用”
横向课题“新型显色离子吸附剂的研制”
近期代表文章：
1. Zhang, Q.; Bu, D.D.; Yu, M.M.*; Zhang, H.Y.*; Li, Z.X.* Synthesis of a NIR fluorescene dye and its application for rapid detection
of HSO3? in living cells. Dyes Pigments, 2021, accepted.
2. Lin,
X.M.; Liu, W.J.; Xu, S.Y.; Li, Z.X.*; Zhang, H.Y.*; Yu, M.M.* Imaging of intracellular
bisulfate based on sensitive ratiometric fluorescent probes. Spectrochim. Acta A, 2021, accepted.
3. Liu,
W.J; Yang, C.C.; Zhang, H.Y.*; Li, Z.X.*; Yu,
M.M.* Colorimetric and
ratiometric fluorescence detection of HSO3? with a NIR
fluorescent dye. J. Fluoresc. 2021, published online, Early
Access.
4. Yang, C.C.; Song, J.S.; Ding, Y.; Ren, H.H.; Yu,
M.M.*; Zhang, H.Y.*; Li, Z.X.* Solvent-dependent tautomeric
equilibrium between fluorescent colorimetric probes with dual
mitochondrial/liposome targetability. Dyes Pigments, 2021, 191, 109377.
5. Bu,
D.D.; Wang, Y.Y.; Wu, N.; Feng, W.; Wei, D.H.; Li,
Z.X.*; Yu, M.M.* A mitochondrial-targeted
ratiometric probe for detecting intracellular H2S with high photostability. Chin. Chem. Lett., 2021, 32, 1799–1802.
6. Zhang, Q.; Song, H.H.; Yu, M.M.*; Zhang, H.Y.*; Li, Z.X.* Preparation of yellow fluorescent N,O-CDs and its application in detection
of ClO-. J. Fluoresc. 2021, 31, 659–666.
7. Yang, C.C.; Li, Y.Y.; Wu, N.; Zhang, Y.C.; Feng, W.; Yu, M.M.*; Li, Z.X.* Ratiometric upconversion luminescence
nanoprobes for quick sensing of Hg2+ and cells imaging. Sens. Actuators B, 2021, 326, 128841.
8. Hou, Y.; Liu, H.X.;
Li, Z.X.*; Zhang, H.Y.*; Wei, L.H.; Yu, M.M.* One-step
synthesis of mitochondrion-targeted fluorescent carbon dots and fluorescence detection
of silver ions. Anal. Methods, 2020, 12,
2835–2840.
9. Bu, D.D.; Song, H.H.; Li, Z.X.*; Wei, L.H.; Zhang, H.Y.*; Yu, M.M.* Carbon-dot-based ratiometric fluorescent probe
of intracellular zinc ion and persulfate ion with low dark toxicity. Luminescence, 2020, 1–9. DOI:
10.1002/bio.3894.
10. Liu, W.J.; Wang, Y.Y.;
Wu, N.; Feng, W.; Li, Z.X.*; Wei, L.H.; Yu, M.M.* A mitochondrion-targeting fluorescent probe
for hypochlorite anion in living cells. Spectrochim. Acta A, 2020, 240, 118564.
11. Li, Y.Y.; Ban, Y.N.;
Wang, R.H.; Wang, Z.; Li, Z.X.*; Fang, C.J.; Yu, M.M.* FRET-based Ratiometric Fluorescent Detection of Arginine in Mitochondrion
with a Hybrid Nanoprobe. Chin. Chem. Lett., 2020, 31, 443–446.
12. Wang,
Y.Y.; Liu, H.X.; Song, H.H.; Yu, M.M.*; Wei,
L.H.; Li, Z.X.* Synthesis of dual-emission fluorescent
carbon quantum dots and their ratiometric fluorescence detection for arginine
in 100% water solution. New
J. Chem., 2019, 43, 13234?13239.
13. Li,
Z.X.; Liu, H.X.; Li,
H.X.; Tsou, Y.H.; Gao, Y.L.; Xu, X.Y.*; Du, W.W.; Wei, L.H.; Yu, M.M.*
Lysosome-targeting NIR Ratiometric Luminecent Upcoversion Nanoprobe toward
Arginine. Sens. Actuators B, 2019, 280,
94–101.
14. Song,
H.H.; Du, W.W.; Liu, C.X.; Li, Z.X.*; Zhang, H.Y.*; Wei, L.H.; Yu, M.M.* Self-Assembled
Micellar Nanosensor toward pH with high photo-stability and its application in
living cells. Sens. Actuators B, 2018, 273, 927–934.
15. Ban,
Y.; Wang, R.H.; Li, Y.; An, Z.; Yu, M.M.*; Fang, C.J.*; Wei, L.; Li, Z.X. Mitochondria-targeted
ratiometric fluorescent detection of hydrazine with fast response time. New
J. Chem., 2018, 42, 2030?2035.
16. Shi, B. J.; He,Y. Y.; Zhang, P. P.; Wang,
Y. L.; Yu, M. M.*; Zhang, H. Y.*; Wei, L. H.; Li, Z. X.* Turn on fluorescent detection of hydrazine with a 1,8-naphthalimde
derivative. Dyes Pigments, 2017,
147, 152–159.
17. He,Y. Y.; Li, Z. X.*; Jia, Q. Y.; Shi, B. J.; Zhang, H. Y.*; Wei, L. H.; Yu, M. M.* Ratiometric
fluorescent detection of acidic pH in lysosome with carbon nanodots. Chin. Chem.
Lett., 2017, 28(10), 1969-1974.
18. Li, H. X;
Dong, H.; Yu, M. M.; Liu, C. X.; Li, Z. X.; Wei, L. H.; Sun, L.
D.; Zhang, H. Y. NIR ratiometric luminescence detection of pH fluctuation in
living cells with hemicyanine derivative-assembled upconversion nanophosphors. Anal. Chem., 2017, 89,
8863?8869.
19. Shi,
B. J.; Qi, S. J.; Yu, M. M.; Liu, C. X.; Li, Z. X.; Wei, L. H.; Ni, Z. H. Colorimetric and fluorescent detection of hydrazine with high sensitivity
and excellent selectivity. Spectrochim. Acta A, 2018, 188, 208–212.
20. He,Y. Y.; Li, Z. X.; Shi, B. J.; An, Z.; Yu, M. M.; Wei, L. H.; Ni, Z. H. A new near-infrared ratiometric fluorescent
probe for hydrazine. RSC Adv., 2017, 7, 25634–25639.
21. Yu, M. M.*; Du, W. W.; Li, H. X.; Zhang, H. Y.*; Li, Z. X.* Near-infrared ratiometric
fluorescent detection of arginine in lysosome with a new hemicyanine derivative. Biosens. Bioelectron., 2017, 92, 385–389.
22. An, Z.; Li, Z. X.*; He, Y.; Shi, B.; Wei, L.; Yu, M. M.* Ratiometric
luminescent detection of hydrazine with a carbon dots-hemicyanine nanohybrid
system. RSC Adv., 2017, 7, 10875–10880.
23. Li, Z. X.;* Zhang, W. Y.; Liu, C. X.; Yu, M. M.*; Zhang,
H. Y.*; Guo, L.; Wei, L. H. A colorimetric and ratiometric fluorescent
probe for hydrazine and its application in living cells with low dark toxicity. Sens. Actuators B, 2017, 241, 665–671.
24. Shi,
B. J.; Gao, Y. L.; Liu, C. X.; Feng, W. Li, Z. X.; Wei, L. H.; Yu, M. M.* A ratiometric fluorescent sensor for pH
fluctuation and its application in living cells with low dark toxicity. Dyes
Pigments, 2017, 136,
522–528.
25. Li,
Z. X.; Li,
H. X.; Shi, C. X.; Yu, M. M.; Wei, L. H.; Ni
Z. H. Nanomolar colorimetric quantitative detection of Fe3+ and PPi with
high selectivity. Spectrochim. Acta A, 2016, 159, 249–253.
26. Yu, M. M.*, Du, W. W.; Zhou, W.; Li, H. X.; Liu,
C. X.; Wei, L. H.; Li, Z. X.*; Zhang, H. Y. A 1,8-naphthalimide-based
chemosensor with an off-on fluorescence and lifetime imaging response for
intracellular Cr3+ and further for S2?. Dyes Pigments, 2016, 126, 279–285.
27. Li,
Z. X.*; Li, H. X.; Shi, C. X.; Zhang, W. Y.; Zhou, W.; Wei, L. H.; Yu, M. M.*
Naked-eye-based highly selective sensing of Fe3+ and further for PPi
with nano copolymer Film. Sens. Actuators B, 2016, 226, 127–134.
28. Yu, M. M.*; Xu, J.;
Peng, C.; Li, Z. X.; Liu, C. X.; Wei, L. H. A novel colorimetric and fluorescent probe for detecting fluoride
anions: from water and toothpaste samples. Tetrahedron, 2016, 72, 273–278.
29. Xu, L. J.; Liang, X. Y.; Zhang, L.; Wu, J. B.; Li, Z. X.; Yu, M. M.*; Wei, L. H.* The
vesicle formation of β-CD and AD
self-assembly of dumbbell-shaped amphiphilic triblock copolymer. Colloid Polym. Sci., 2016, 294, 145–155.
30. Zhang, W. Y.; Liu, X. J.; Zhang, H. Y.; Feng, C. C.; Liu, C. X.; Yu, M. M.*; Wei, L. H.; Li, Z. X.* A fluorescent probe for benzenethiols and
its application on test paper, in water samples and living cells. J. Mater.
Chem. C, 2015, 3,
8248–8254.
31. Liu, C. X.;
Shi, C. X.; Li, H. X.; Du, W. W.; Li, Z. X.*; Wei, L. H.; Yu, M. M.*
Nanomolar fluorescent quantitative detection of formaldehyde with a
8-hydroxyquinoline derivative in aqueous solution and electrospun nanofibers. Sens.
Actuators B, 2015, 219, 185–191.
32. Li, Z. X.*; Zhang, W. Y.; Liu, X. J.; Liu, C. X.; Yu, M. M.*; Wei, L. H.* Naked-eye-based selective detection of
pyrophosphate with Zn2+ complex in aqueous solution and electrospun
nanofibers. RSC Adv., 2015, 5, 25229–25235.
33. Liu, C. X.; Xu, J.; Yang, F.; Zhou, W.; Li, Z. X.*; Wei, L. H.; Yu, M. M.* Nanomolar Cu2+ and F– naked-eye detection with a 1,8-naphthalimide-based colorimetric probe. Sens. Actuators B, 2015, 212, 364–370.
34. Du, W. W.; Xu,
J.; Li, H. X.; Feng, C. C.; Yu, M. M.*; Li Z. X.;* Wei L. H. Naked-eye and fluorescent detection of basic pH and F? with a 1,8-naphthalimide-based multifunctional
probe. RSC Adv., 2015, 5,
15077–15083.
35. Zhou, W.; Dong, H.; Yan, H.; Shi, C. X.; Yu, M. M.*; Wei, L.
H.; Li, Z. X.* HCHO-reactive
molecule with dual-emission-enhancement property for quantitatively detecting HCHO
in near 100% water solution. Sens.
Actuators B, 2015, 209, 664–669.
36. Liu, X. J.; Zhang, W.Y.; Li, C. X.; Zhou, W.;
Li, Z. X.*; Yu, M. M.*; Wei, L. H. Nanomolar detection of Hcy, GSH
and Cys in aqueous solution, test paper and living cells. RSC Adv., 2015, 5, 4941–4946.
37. Li, Z. X.*;
Liu, X. J.; Zhao, W. Y.; Wang, S.; Zhou, W.; Wei, L. H.; Yu, M. M.* Naked-eye
detection of C1–C4 alcohols based on ground-state intramolecular proton transfer. Anal. Chem., 2014, 86,
2521?2525.
38. Su, Z.; Huang,
S. S.; He, M.; Dong, C. F.; Wu, L. Z.; Li, C. H.; Liu, J. X.; Yu, M. M.*; Wei, L. H.* Synthesis and antibacterial performance of silver bromide
and silver nanoparticles J. Nanoeng. and
Nanomanuf. 2014, 4(4), 330?335.
39. Liu, X. J.;
Chen, M. X.; Liu, Z. P.; Yu, M. M.*; Wei,
L. H.; Li, Z. X.* Synthesis
of 1,8-naphthyridine and BF2-based isomers and their application in
fluorogenic sensing Cd2+ Tetrahedron 2014, 70,
658?663.
40. Yu, M. M.*; Yuan,
R. L.; Shi, C. X.; Zhou, W.; Wei, L. H.; Li, Z. X.* 1,8-Naphthyridine
and 8-hydroxyquinoline modified Rhodamine B derivatives: “Turn-on” fluorescent
and colorimetric sensors for Al3+ and Cu2+ Dyes Pigments 2013, 99, 887?894.
41. Li, X. Y.; Yu, M. M.; Liu, X. J.; Yang,
F. L.; Wei,
L. H.; Li, Z. X.* A dual-mode
ratiometric and on?off fluorescent Al3+/Cu2+-chemosensor
and the detection of F?/Al3+ with ‘in situ’ prepared Al3+/Cu2+ complex in aqueous solution. New J. Chem. 2013, 37, 2257?2260.
42. Li, H. Q.; Li,
Z. X.*; Wu, L. Z.; Zhang, Y. N.; Yu, M. M.*; Wei, L. H.* Constructing
metal nanoparticle multilayers with polyphenylene dendrimer/gold nanoparticles via “click” chemistry. Langmuir 2013, 29, 3943?3949.
43. Li, Z. X.;
Zhou, W.; Zhang, L. F.; Yuan, R. L.; Liu, X. J.; Wei, L. H.; Yu, M. M.* Highly selective ratiometric fluorescent detection of Fe3+ with a
polyphenyl Derivative, J. Lumin. 2013, 136, 141?144.
44. Li, Z. X.; Zhao, W. Y.; Li, X. Y.; Zhu, Y. Y.; Liu, C. M.; Wang, L. N.; Yu, M. M.*; Wei, L. H.; Tang, M. S.; Zhang, H. Y.* 1,8-Naphthyridine-derived Ni2+/Cu2+-selective
fluorescent chemosensor with different charge transfer processses. Inorg. Chem. 2012, 51, 12444?12449.
45. Wang, L. N., Yu,
M. M.*, Liu, Z. T., Zhao, W. Y., Li, Z. X.,* Ni, Z. H., Li, C. C., Wei, L. H.* A visible
light excitable “on-off” and “green-red” fluorescent chemodosimeter for Ni2+/Pb2+ New J. Chem. 2012, 36, 2176–2179.
46. Li, Z. X.; Zhang, L. F.; Li, X. Y.; Guo, Y. K.; Ni, Z. H.; Chen, J. H.; Wei, L.
H.; Yu, M. M.* A fluorescent color/intensity changed chemosensor for Fe3+ by
photo-induced electron transfer (PET) inhibition of fluoranthene derivative. Dyes
Pigm. 2012, 94, 60–65.
47. Huiqiang Li, Zhanxian
Li, Linzhi Wu, Fang Liu, Jie Zhou, Miao Luan, Mingming Yu*, Liuhe Wei* Water-Soluble
Starlike Poly(acrylic acid) Graft Polymer: Preparation and Application as
Templates for Silver Nanoclusters Polym. Bull., 2012, 68, 2229–2242.
48. Zhanxian
Li, Wanying Zhao, Yuna Zhang, Lifeng Zhang, Mingming Yu*, Jinxia Liu* and Hongyan Zhang* An “off-on”
fluorescent chemosensor of selectivity to Cr3+ and its application
to MCF-7 cells Tetrahedron, 2011, 67, 7096–7100.
49. Zhan-Xian Li, Li-Feng Zhang, Wan-Ying Zhao, Xiao-Ya Li, Yong-Kai
Guo, Ming-Ming Yu*, Jin-Xia
Liu* Fluoranthene-based pyridine as fluorescent chemosensor for Fe3+ Inorg. Chem.
Commun., 2011, 14, 1656–1658.
50. Zhanxian Li, Lifeng Zhang, Lina Wang,
Yongkai Guo, Lianheng Cai, Mingming
Yu,*
Liuhe Wei* Highly Sensitive and
Selective Fluorescent Sensor for Zn2+/Cu2+ and New Approach for Sensing Cu2+ by Central Metal Displacement Chem. Commun., 2011, 47, 5798–5800.
51. Zhanxian Li, Mingming Yu,* Lifeng
Zhang, Ming Yu, Jinxia Liu, Liuhe Wei,* and Hongyan Zhang* A “switching
on” fluorescent chemodosimeter of selectivity to Zn2+ and its application to MCF-7 cells Chem. Commun., 2010, 46, 7169–7171.
52. Ming Ming Yu, Xia
Li, Miao Luan, Jun Na Gao, Qiu Zhi Shi, Ming Sheng Tang, Liu He Wei
An improved synthesis of bis(cyclopentadienone) Chin. Chem. Lett., 2010, 21, 1157–1161.
53. Ming-Ming Yu, Zhan-Xian Li, Liu-He Wei, Dong-Hui Wei, Ming-Sheng Tang A
1,8-Naphthyridine-based Fluorescent Chemodosimeter for the Rapid Detection of
Zn2+ and Cu2+ Org.
Lett. 2008, 22(10), 5115–5118.
54. Ming-Ming Yu, Hui-Zhong Kou, Zhong-Hai Ni, Chong-Chao Zhao, Ai-Li Cui Synthesis and
Study of Ferromagnetic μ1,1-Azido-Bridged Manganese(II) Dinuclear
Complexes with S=5 and S = 5 × 2 2 Ground State Eur. J. Inorg. Chem. 2007,
5670– 5676.
授权专利：
· 于明明、李占先、杜玮玮、李海霞、魏柳荷，一种溶酶体定位荧光探针在近红外比率检测肼中的应用。2016.10.20，中国，专利号：ZL201610923191.8
· 于明明、施冰杰、刘春霞、李占先、魏柳荷，一种线粒体靶向的pH敏感的比率型荧光探针及其制备方法和应用。2016.07.06，中国，专利号：ZL201610221971.8
· 于明明、张文英、李占先、石彩霞、周婉、魏柳荷，一种高分子比色纳米薄膜材料及其制备方法以及用于Fe3+和焦磷酸根检测方面的应用。2015.05.26，中国，专利号：ZL201510292665.9
· 于明明、李海霞、严晗、周婉、李占先、魏柳荷，一种甲醛快速检测试剂及其制备方法与应用。2016.11.02，中国，专利号：ZL201410500026.2
· 于明明、张文英、刘兴江、周婉、李占先、魏柳荷，一种检测焦磷酸根的纳米纤维膜试条、制备方法及其应用。2015.11，中国，专利号：ZL201410402826.0
· 于明明、李占先、魏柳荷、刘兴江，一种氟硼荧光衍生物、其制备方法及应用。2015.11，中国，专利号：ZL201310171197.0
· 于明明、乔钰茜、李占先、魏柳荷、郭永开，2,4-二苯基-5,6-二吡啶基-苯酚及其制备。2015.6，中国，专利号：ZL201310518992.2
· 李占先、班亚楠、于明明、李海霞、刘春霞、魏柳荷，一种用于制备近红外比率发光上转换纳米材料的化合物、制备方法及应用。2016.12.01，中国，专利号：ZL201611120950.3
· 李占先、于明明、魏柳荷、刘兴江、赵万莹、周婉，一种低级醇检测探针、制备方法及应用。2015.4，中国，专利号：ZL201310198342.4
· 于明明、李占先、魏柳荷、张利锋、赵万莹、王丽娜，苯衍生物金属离子荧光探针及其应用。2014.4，中国，专利号：ZL201110169893.9
· 李占先、于明明、张利锋、虞明、魏柳荷、刘金霞，一种检测细胞内锌离子的分子荧光开关及其应用。2013.4，中国，专利号：ZL201010181802.9。
· 李占先、于明明、魏柳荷、张利锋、赵万莹、王丽娜，萘联苯衍生物金属离子荧光探针的制备及其识别检测生物样品或环境中Fe3+和/或Cu2+的应用。2013.4，中国，专利号：ZL201110169892.4。
教育教学相关
2014年和2016年年终考核被评为优秀；
2011年发表教改论文一篇（物理化学实验教学的体会与思考）；
2016年发表教改论文一篇（高校全员育人的三级管理体系新探）；
2013、2014、2015和2016年化学学院高分子化学理论课网上教评均为优秀；
2013、2014和2015年药学院物理化学理论课网上教评优秀；
2013、2014和2016年物理化学实验课网上教评优秀；
2015年综合化学实验课网上教评优秀；
2013年和2014年两次被评为平安校园工作先进个人，2015年被评为工会工作积极分子；
先后担任2014级化学8班班主任和2016级化学1班班主任，作为2014级化学8班班主任2015年和2016年两次被评为郑州大学优秀班主任；
指导的本科生毕业论文多次获得院优秀毕业论文（齐素杰、杨帆等）。
培养研究生情况
在读研究生
· 卜丹丹、杨晨辰、刘文静（18级）
· 刘文洁、张强、林雪梅（19级）
· 赵晓军、魏万恒、张申、王蕙丽（20级）
已毕业研究生
· 张利锋（08级）
· 王丽娜（09级）、赵万莹（09级）
· 郭永开（10级）、李小鸭（10级）
· 袁瑞丽（11级）、刘兴江（11级）
· 周婉、许洁、石彩霞（12级）
· 刘春霞、张文英（13级）
· 杜玮玮、何杨杨、安桢（14级）李海霞（11级本硕）
· 施冰杰（15级）
· 班亚楠、宋欢欢、刘含笑（16级）
· 王钰莹、李月月、侯玥（17级）
研究生及本科生所获部分奖励
2013年
袁瑞丽获得康龙化成奖学金
袁瑞丽、周婉获得国家奖学金
2014年
刘兴江获得校级及省级优秀毕业生
刘兴江获得省级优秀毕业论文
张文英获得郑州大学优秀科研奖
2015年
周婉获得郑州大学优秀毕业生
齐素杰获得郑州大学优秀毕业论文
张文英、刘春霞获得国家奖学金
2016年
杨帆获得院优秀毕业论文
杜玮玮、施冰杰获得郑州大学优秀科研奖
李海霞、杜玮玮获得国家奖学金
张文英获得省级优秀毕业论文
2017年
李海霞、杜玮玮获得郑州大学优秀毕业生
杜玮玮获得省级优秀毕业论文
施冰杰或省级大学生实验创新项目优秀奖