writer：Shuaishuai Yuan, Xiuxia Sun, Yong Shen, and Zhibo Li*
keywords：antibacterial, electrospinning, hemostasis, poly(4-hydroxybutyrate) (P4HB), poly(ethylene glycol), zinc oxide
source：期刊
specific source：Macromolecular Bioscience
Issue time：2022年

Antibacterial and hemostatic properties are of great importance to wound

dressing in treating trauma. Poly(4-hydroxybutyrate) (P4HB), an U.S. Food

and Drug Administration (FDA)-approved bioabsorbable polyester, is used as

dermal substitutes to prevent sever wound contraction and improve wound

healing. However, P4HB fibrous mats are not efficient in halting bleeding and

preventing bacterial associated infection. Here the authors prepare a new kind

of wound dressing by incorporating poly(ethylene glycol) (PEG) and zinc oxide

(ZnO) nanoparticles into the P4HB matrix by using electrospinning method.

The in vitro results reveal that the P4HB/PEG/ZnO dressings can

synergistically help blood clotting, prevent bacteria adhesion, and kill bacteria

efficiently. It’s found that the bactericidal activity of the bioactive

P4HB/PEG/ZnO dressings is related to the release of Zn2+ ions rather than

reactive oxygen species (ROS) under dark condition. The in vivo antibacterial

evaluation indicates that the bioactive P4HB/PEG/ZnO dressings can

successfully prevent wound infections in Sprague–Dawley (SD) rats’ skin

defect model. The in vivo hemostatic experiments evaluated in the rabbit ear

injury model further confirm that the bioactive P4HB/PEG/ZnO dressings

have excellent hemostatic performance. Hence, this study demonstrates that

the bioactive P4HB/PEG/ZnO dressings with hemostatic and bactericidal

properties have great potential in possible clinical applications.