writer：Xiuxia Sun, Qi Chen, Angelique A. Guan, Shuaishuai Yuan*, Zhibo Li*
keywords：hernia repair, nanofibrousmembranes, perfluorocarbon oil, peritoneal adhesions, poly(4-hydroxybutyrate) (P4HB)
source：期刊
specific source：Macromolecular Bioscience
Issue time：2023年

Abdominal wall defect caused by surgical trauma, congenital rupture, or

tumor resection may result in hernia formation or even death. Tension-free

abdominal wall defect repair by using patches is the gold standard to solve

such problems. However, adhesions following patch implantation remain one

of the most challenging issues in surgical practice. The development of new

kinds of barriers is key to addressing peritoneal adhesions and repairing

abdominal wall defects. It is already well recognized that ideal barrier

materials need to have good resistance to nonspecific protein adsorption, cell

adhesion, and bacterial colonization for preventing the initial development of

adhesion. Herein, electrospun poly(4-hydroxybutyrate) (P4HB) membranes

infused with perfluorocarbon oil are used as physical barriers. The oil-infused

P4HB membranes can greatly prevent protein attachment and reduce blood

cell adhesion in vitro. It is further shown that the perfluorocarbon oil-infused

P4HB membranes can reduce bacterial colonization. The in vivo study reveals

that perfluoro(decahydronaphthalene)-infused P4HB membranes can

significantly prevent peritoneal adhesions in the classic abdominal wall

defects’ model and accelerate defect repair, as evidenced by gross

examination and histological evaluation. This work provides a safe fluorinated

lubricant-impregnated P4HB physical barrier to inhibit the formation of

postoperative peritoneal adhesions and efficiently repair soft-tissue defects.