writer：Lilin Zhou, Zhinan Cai, Jinying Yuan*, Yan Kang, Weizhong Yuan, Dezhong Shen
keywords：superparamagneticmaterials; ATRP; targeted drug release; fluorescence; pH-responsive
source：期刊
specific source：Polymer International, 2011, 60 (9), 1303-1308
Issue time：2011年

Multifunctional hybrid nanoparticles, Fe3O4@poly[(2-dimethylamino)ethyl ethacrylate]-block-poly(2-hydroxyethyl methacrylate)-graft-carbazole, with pH-responsivity, superparamagnetism and fluorescence for targeted drug delivery and
release have been synthesized. The nanoparticles have a core-shell structure as determined from transmission electron microscopy, pH-responsivity as determined from hydrodynamic radius analysis, superparamagnetism as determined from
vibrating samplemagnetometry and fluorescence as determined from fluorescence spectroscopy and fluorescencemicroscopy. The release behavior ofmodel drug progesterone indicates that the release rate can be effectively controlled by altering the pH of the environment. The multifunctional nanoparticles could be applied extensively in targeted drug delivery and release, and with fluorescence they can serve as efficient tracers to record magnetic targeting routes.