姚菊明,男,1970年12月出生,工学博士,教授,博士生导师,浙江理工大学材料与纺织学院院长。1993年7月毕业于浙江丝绸工学院。1993年9月-1999年9月历任浙江农业大学和浙江大学助教、讲师。1999年10月-2003年3月,受日本政府资助在东京农工大学工学部生命工学科攻读博士课程,获工学博士学位。2003年4月-2004年3月任东京农工大学VBL(Venture Business Laboratory)实验室博士后。2004年4月回国,任浙江理工大学副教授。2006年11月破格晋升为教授。2007年1月被聘为博士生导师。入选2007年教育部“新世纪优秀人才支持计划”,浙江省第十届青年科技奖获得者。主持包括5项国家自然科学基金和1项科技部“政府间国际科技创新合作”重点专项在内项目十余项。主要研究方向:生物高分子(蛋白质、纤维素)材料的功能化利用。已发表学术论文100余篇,其中SCI收录90余篇。获2007年度、2009年度浙江省科学技术二等奖各1项(第一、三完成人),2015年度浙江省科学技术一等奖1项(第二完成人)。兼任浙江省现代纺织技术协同创新中心主任、浙江省纺织材料与加工技术工程实验室主任、浙江省材料研究学会副理事长、教育部高等学校纺织类专业教学指导委员会纤维材料分委员会副主任委员、浙江省高等学校本科教学材料类专业教学指导委员会委员。
(一)代表性SCI论文:
(1) Yao,
J.M.; Masuda,
H.; Zhao, C.; Asakura, T. Artificial spinning and characterization of silk
fiber from Bombyx mori silk fibroin in hexafluoroacetone hydrate. Macromolecules, 2002, 35, 6-9.
(2)
Asakura, T.; Yao, J.M.; Yamane, T.; Umemura, K.; Ulrich A. S.
Heterogeneous structure of silk fibers from Bombyx mori resolved by 13C solid-state NMR spectroscopy. J.
Am. Chem. Soc., 2002, 124, 8794-8795.
(3)
Asakura, T.; Yao,
J.M. 13C CP/MAS NMR study on structural heterogeneity in Bombyx mori silk fiber
and their generation by stretching. Protein Sci., 2002, 11,
2706-2713.
(4) Yao,
J.M.; Asakura,
T. Synthesis and structural characterization of silk-like materials
incorporated with an elastic motif. J. Biochem., 2003, 133,
147-154.
(5) Yao,
J.M.; Nakazawa,
Y.; Asakura, T. Structures of Bombyx mori and Samia cynthia ricini silk fibroins studied with solid-state NMR. Biomacromolecules, 2004, 5, 680-688.
(6) Yao,
J.M.; Ohgo, K.; Sugino, R.; Kishore, R.; Asakura, T. Structural
analysis of Bombyx mori silk fibroin peptides with formic acid treatment
studied by high-resolution solid-state 13C NMR spectroscopy. Biomacromolecules, 2004, 5, 1763-1769.
(7) Yao,
J.M.; Yanagisawa, S.; Asakura, T. Design, expression and
characterization of collagen-like proteins based on the cell adhesive and
crosslinking sequences derived from native collagens. J. Biochem., 2004, 136, 643-649.
(8) Yao,
J.M.; Zhang, G.Q.; Lei,
C.H. Conformational transformation exhibited by the peptide extracted from
crystalline region of Bombyx mori silk fibroin in solid and solution
states.. Chin. J. Chem. 2006, 24, 705-710. (通讯作者)
(9) 姚菊明, 祝永强, 李媛, 励丽. 桑蚕丝-RGD融合蛋白的固态结构及其细胞粘附性分析. 化学学报, 2006, 64, 1273-1278. (通讯作者)
(10) 姚菊明, 魏克民, 励丽, 孔祥东, 祝永强, 林凤. 桑蚕丝素蛋白初始结构对其矿化作用的影响. 化学学报, 2007, 65, 635-639. (通讯作者)
(11)
Asakura, T.; Yao, J.M.; Yang,
M.Y.; Zhu, Z.H.; Hirose, H. Structure of the spinning apparatus of a wild
silkworm Samia cynthia ricini and molecular dynamics calculation on the
structural change of the silk fibroin. Polymer, 2007, 48,
2064-2070.
(12) 白利强, 马廷方, 姚菊明. Cecropin B抗菌肽接枝丝素蛋白膜的制备和表征. 高等学校化学学报, 2007, 28, 1593-1597. (通讯作者)
(13) Li,
L.; Wei, K.M.; Lin, F.; Kong, X.D.; Yao, J.M. Effect of silicon
on the formation of silk fibroin/calcium phosphate composite. J. Mater.
Sci.: Mater. Med., 2008, 19, 577-582. (通讯作者)
(14) Bai,
L.Q.; Zhu, L.J.; Min, S.J.; Liu, L.; Cai, Y.R.; Yao, J.M. Surface modification and properties of Bombyx mori
silk fibroin films by antimicrobial peptide. Appl. Surf. Sci., 2008, 254, 2988-2995. (通讯作者)
(15) Liu,
L.; Liu, J.Y. Wang, M.Q.; Min, S.J.; Cai, Y.R.; Zhu, L.J.; Yao, J.M. Preparation and characterization of
nano-hydroxyapatite/silk fibroin porous scaffolds. J. Biomater. Sci. Polymer Edn., 2008, 19, 325-338.(通讯作者)
(16) Du,
C.L.; Wang, M.Q.; Liu, J.Y.; Pan, M.L.; Cai, Y.R.; Yao, J.M. Improvement of thermostability of recombinant
collagen-like protein by incorporating a foldon sequence. Appl. Microbiol. Biotechnol., 2008, 79, 195-202.(通讯作者)
(17) Lin,
F.; Li, Y.C.; Jin, J.; Cai, Y.R.; Wei, K.M.; Yao, J.M. Deposition behavior and properties of silk fibroin
scaffolds soaked in simulated body fluid. Mater. Chem. Phys., 2008, 111,
92-97.(通讯作者)
(18) 刘琳, 孔祥东, 蔡玉荣, 姚菊明. 纳米羟基磷灰石/丝素蛋白复合支架材料的降解特性及生物相容性研究. 化学学报, 2008, 66, 1919-1923.(通讯作者)
(19) Li,
Y.C.; Cai, Y.R.; Kong, X.D.; Yao, J.M. Anisotropic growth of
hydroxyapatite on the silk fibroin films. Appl. Surf. Sci., 2008, 255, 1681-1685.(通讯作者)
(20) Du,
C.L.; Jin, J.; Li, Y.C.; Kong, X.D.; Wei, K.M.; Yao, J.M. Novel
silk fibroin/hydroxyapatite composite films: structure and properties. Mater. Sci. Eng. C., 2009, 29,
62-68.(通讯作者)
(21) Li,
R.J.; Fei, J.M.; Cai, Y.R.; Li, Y.F.; Feng, J.Q.; Yao, J.M. Cellulose whiskers extracted from mulberry: a
novel biomass production. Carbohydrate Polym., 2009, 76, 94-99.(通讯作者)
(22) Cai,
Y.R.; Jin, J.; Mei, D.P.; Xia, N.X.; Yao,
J.M. Effect of silk sericin on assembly of hydroxyapatite nanocrystals
into enamel prism-like structure. J.
Mater. Chem., 2009, 19, 5751-5758.(通讯作者)
(23) 刘琳, 孔祥东, 李玉成, 蔡玉荣, 姚菊明. 预处理对丝素蛋白膜调控羟基磷灰石晶体生长的影响. 高等学校化学学报, 2009, 30(10), 1987-1991.(通讯作者)
(24) 金君, 梅丹平, 夏年鑫, 王秀华, 蔡玉荣, 姚菊明. 类牙釉状丝胶蛋白/羟基磷灰石复合材料的合成及表征. 化学学报, 2009,67(21),2500-2504.(通讯作者)
(25) Liu, L.; Cao, J.; Huang, J.; Cai, Y.R.; Yao, J.M. Extraction of pectins with different degrees of
esterification from mulberry branch bark. Bioresource Technol., 2010, 101, 3268-3273.(通讯作者)
(26) 邵锋伟, 蔡玉荣, 姚菊明. 多孔羟基磷灰石纳米球作为抗坏血酸载体的研究. 高等学校化学学报, 2010, 31(6), 1093-1097.(通讯作者)
(27) Cai,
Y.R.; Yao, J.M. Effect of proteins on the synthesis and assembly of
calcium phosphate nanomaterials. Nanoscale, 2010, 2, 1842-1848. (invited review) (通讯作者)
(28) Cai,
Y.R.; Mei, D.P.; Jiang, T.; Yao, J.M. Synthesis of oriented
hydroxyapatite crystals: effect of reaction conditions in the presence or
absence of silk sericin. Mater. Lett., 2010,
64, 2676-2678.(通讯作者)
(29) Liu,
L.; Yao,
J.M. Wet-spinning of reinforced artificial silk hybrid fibres by cellulose
whiskers. Adv. Mater. Res., 2011,
175-176, 272-275. (通讯作者)
(30) Pan,
M.L.; Kong, X.D.; Cai, Y.R.; Yao, J.M. Hydroxyapatite coating on
the titanium substrate modulated by a recombinant collagen-like protein. Mater.
Chem. Phys., 2011, 126, 811-817. (通讯作者)
(31) 夏年鑫, 蔡玉荣, 姚菊明. 纳米银的绿色合成: 丝胶蛋白作为还原剂和分散剂. 化学学报, 2011, 69(11), 1321-1326.(通讯作者)
(32) Liu,
L.; Liu, J.Y.; Kong, X.D.; Cai, Y.R.; Yao,
J.M. Porous composite scaffolds of hydroxyapatite/silk fibroin via
two-step method. Polym. Adv. Technol., 2011,
22, 909-914.(通讯作者)
(33) Liu,
L.; Jiang, T.; Yao, J.M. A two-step chemical process
for the extraction of cellulose fiber and pectin from
mulberry branch bark efficiently. J. Polym. Environ., 2011, 19, 568-573.(通讯作者)
(34) Jiang,
T.; Liu, L.; Yao, J.M. In situ deposition of silver nanoparticles on the
cotton fabrics. Fiber Polym., 2011,
12(5), 620-625.(通讯作者)
(35) Xia,
N.X.; Cai, Y.R.; Jiang, T.; Yao, J.M. Green synthesis of silver
nanoparticles by chemical reduction with hyaluronan. Carbohydrate Polym., 2011, 86, 956-961.(通讯作者)
(36) Huang,
J.; Liu, L.; Yao, J.M. Electrospinning of Bombyx mori silk fibroin nanofiber mats reinforced by cellulose
nanowhiskers. Fiber Polym., 2011,
12(8), 1002-1006.(通讯作者)
(37) Zhao,
H.X.; Dong, W.J.; Zheng, Y.Y.;
Liu, A.P.; Yao, J.M.; Li, C.R.; Tang, W.H.; Chen, B.Y.; Wang, G.; Shi, Z. The structural and biological properties of hydroxyapatite-
modified titanate nanowire scaffolds. Biomaterials, 2011, 32(25), 5837-5846.(通讯作者)
(38) Chen, Z.Q.; Fu, Y.Y.; Cai, Y.R.; Yao, J.M. Effect of amino acids on the crystal growth of
hydroxyapatite. Mater. Lett., 2012,
68, 361-363.(通讯作者)
(39)
Wu, F.; Zhang, Y.; Liu, L.; Yao, J.M. Synthesis and characterization of a novel cellulose-g-poly(acrylic
acid-co-acrylamide) superabsorbent composite based on flax yarn waste.
Carbohydrate Polym., 2012, 87,
2519-2525.(通讯作者)
(40) Li,
R.J.; Zhang, Y.H.; Zhu, L.J.; Yao,
J.M. Fabrication and characterization of silk fibroin/poly(ethylene
glycol)/cellulose nanowhisker composite films. J. Appl. Polym. Sci., 2012, 124(3), 2080-2086.(通讯作者)
(41) Shao,
F.W.; Liu, L.; Fan, K.J.; Cai, Y.R.; Yao,
J.M. Ibuprofen loaded porous calcium phosphate nanospheres for skeletal
drug delivery system. J. Mater. Sci., 2012,
47, 1054-1058.(通讯作者)
(42) 马寅孙, 蔡玉荣, 刘琳, 姚菊明. 肝素化丝素支架作为骨形态发生蛋白-2缓释载体的研究. 化学学报, 2012, 70(4), 479-484.(通讯作者)
(43)
Zhang, Y.; Wu, F.; Liu, L.; Yao, J.M. Synthesis and urea
sustained-release behavior of an eco-friendly superabsorbent based on flax yarn
wastes. Carbohydrate Polym., 2013,
91, 277-283.(通讯作者)
(44) Liang,
X.Y.; Zhang, Y.; Liu, L.; Yao, J.M. Synthesis and urea-loading of an eco-friendly superabsorbent composite based on
mulberry branches. BioResources, 2013,
8(1), 130-144. (通讯作者)
(45) Gao, C.; Cai, Y.R.; Kong, X.D.; Han, G.X.; Yao,
J.M. Development and characterization of injectable chitosan-based
hydrogels containing dexamethasone/rhBMP-2 loaded hydroxyapatite nanoparticles.
Mater. Lett., 2013, 93, 312-315(通讯作者)
(46) Liu, L.;
Hu, D.D., Xu, G.K.; Shou, L.W.; Yao, J.M. Fabrication and
evaluation of polyurethane-based
asymmetric membranes. J. Mater. Sci., 2013,
48, 1902-1910. (通讯作者)
(47) Wang, Y.Q.;
Liu, L.; Cai, Y.R.; Chen, J.J.; Yao,
J.M. Preparation and photocatalytic activity of cuprous oxide/carbon nanofibres composite films. Appl. Surf. Sci., 2013, 270, 245-251. (通讯作者)
(48) Yu, H.Y.; Qin, Z.Y.; Liu, L.; Yang, X.G.; Zhou, Y.; Yao, J.M. Comparison of the reinforcing effects for cellulose nanocrystals obtained by
sulfuric and hydrochloric acid hydrolysis on the mechanical and thermal
properties of bacterial polyester. Composite
Sci. Tech., 2013, 87, 22-28. (通讯作者)
(49) Ma, L.;
Zhang, Y.; Cao, J.; Yao, J.M. Preparation of unmodified
cellulose nanocrystals from Phyllostachys
heterocycla and their biocompatibility evaluation. BioResources, 2014, 9(1),
210-217.(通讯作者)
(50) Yu, J.H.; Chu, X.B.; Cai, Y.R.; Tong, P.J.; Yao, J.M. Preparation and characterization
of antimicrobial nano-hydroxyapatite composites. Mater. Sci.
Eng. C, 2014, 37, 54-59. (通讯作者)
(51) Liu H.Y.;
Zhang Y.; Yao, J.M. Preparation and properties of an eco-friendly superabsorbent
based on flax yarn waste for sanitary napkin applications. Fibers Polym., 2014,
15(1), 145-152.(通讯作者)
(二)参编论著:
(1) Yao, J.M. and Asakura, T. Silks, In Encyclopedia of
Biomaterials and Biomedical Engineering (Eds., Wnek, G.E. and Bowlin,
G.L.). Marcel Dekker, Inc., New York, 2004, pp 1363-1370.
(三)授权发明专利:
(1) 姚菊明。一种重组动物丝-RGD融合蛋白及其生物合成方法。专利号:ZL 200610049415.3(2008年1月18日授权)。
(2) 姚菊明。一种重组胶原蛋白及其合成和表达纯化方法。专利号:ZL
200610048946.0(2008年6月4日授权)。
(3) 姚菊明,励丽,孔祥东。一种硅调控丝蛋白/磷酸钙盐复合材料制备的方法。专利号:ZL 200610053416.5(2008年7月16日授权)。
(4) 姚菊明,储诚灿,赵洒,王枝萍,黄辉。一种桑枝皮中各组分的提取和分离方法。专利号:ZL
201110041431.9(2012年5月9日授权)
(5) 姚菊明,张艳红。一种骨形态发生蛋白-2的生物合成方法与应用。专利号:ZL 201010149133.7(2012年10月3日授权)。
(6) 姚菊明,吴娟红,沈凯,蔡玉荣。两步法制备羟基磷灰石-丝素蛋白复合支架材料的方法。专利号:ZL
200910095563.2(2012年10月10日授权)。
(7) 姚菊明,王元前,陈建军。一种静电纺丝制备SiC/C纳米纤维膜的方法。专利号:ZL 201110208710.X(2013年5月1日授权)。
(8) 姚菊明,吴芳,刘琳。一种纤维素基高吸水保水树脂的制备方法。专利号:ZL 201110070555.X(2013年6月5日授权)。
(四)获奖情况:
(1) 姚菊明,冯新星,陈文兴,孔祥东,姚玉元,张华鹏,郭玉海。桑蚕丝素蛋白结构基础上的功能化研究。浙江省人民政府,浙江省科学技术二等奖(2007年)。
(2) 马廷方,张祖琴,姚菊明,冯新星,陈柳玉,雷彩虹,励丽,李媛,张忠信。抗菌肽涂层仿真丝绸面料的开发研究。浙江省人民政府,浙江省科学技术二等奖(2009年)。
(五)主持的主要科研项目:
(1) 重组丝蛋白的分子自我组装和结构调控的研究,国家自然科学基金(20404011),2005.1-2007.12;
(2) 剪切诱导重组丝蛋白/无机质复合体系的结晶生长和结构演变,国家自然科学基金(10672145),2007.1-2008.12;
(3) 丝胶蛋白/磷酸钙复合材料的形成机理及其性能研究,国家自然科学基金(51172207),2012.1-2015.12;
(4) 丝胶蛋白微胶囊的仿生制备及其表面矿化修饰的研究,国家自然科学基金(51372226),2014.1-2017.12;