Antimicrobial Metallopolymers and Their Bioconjugates with Conventional Antibiotics against Multidrug-Resistant Bacteria
作者：Jiuyang Zhang, Yung Pin Chen, Kristen P. Miller, Mitra S. Ganewatta, Marpe Bam, Yi Yan, Mitzi Nagark, Alan W. Decho, Chuanbing Tang*
关键字：antibacterial, metallocenium, superbug
论文来源：期刊
具体来源：J. Am. Chem. Soc. 2014, 136, 4873-4876
发表时间：2014年
Bacteria are now becoming more resistant to most conventional antibiotics. Methicillin-resistant Staphylococcus aureus (MRSA), a complex of multidrugresistant Gram-positive bacterial strains, has proven especially problematic in both hospital and community settings by deactivating conventional β-lactam antibiotics, including penicillins, cephalosporins, and carbapenems, through various mechanisms, resulting in increased mortality rates and hospitalization costs. Here we introduce a class of charged metallopolymers that exhibit synergistic effects against MRSA by efficiently inhibiting activity of β-lactamase and effectively lysing bacterial cells. Various conventional β-lactam antibiotics, including penicillin-G, amoxicillin, ampicillin, and cefazolin, are protected from β-lactamase hydrolysis via the formation of unique ion-pairs between their carboxylate anions and
cationic cobaltocenium moieties. These discoveries could provide a new pathway for designing macromolecular scaffolds to regenerate vitality of conventional antibiotics
to kill multidrug-resistant bacteria and superbugs.