作者：Tuanwei Liu, Ping Zhang, Xiaoying Huang, Xiaoxuan Chi, Zinan Li, Zhide Zhang, Dian-Shun Guo, Xinlin
关键字：Nitric oxide, targeting theranostic, synergistic effect, core-shell magnetic nanoparticles
论文来源：期刊
具体来源：Colloid Surf. B 173 (1), 356-365 (2019). https://doi.org/10.1016/j.colsurfb.2019.05.075
发表时间：2019年

The external force guided targeting strategy, as well as the in vivo active targeting

strategy based on “ligands-receptors” on the targeting cells and tissues have attracted

much research interest. Herein, a kind of hyaluronic acid (HA) and folic acid (FA)

modified magnetic S-nitrosothiols core-shell nanoparticles for nitric oxide (NO)

control release as dual-tumor targeting theranostic platform were described,

combining the external guidance and internal active targeting properties. Confocal

microscopy assay and cells cytotoxicity experiments confirmed the active tumor cells

targeting recognition, cells uptake, and NO initiated cytotoxicity of the HA-FA

external functional layer modified S-nitrosothiols nanoparticles in vitro. In vivo

magnetic resonance imaging (MRI) characterization, bio-distribution assay in organs

and tumor, significant tumor inhibition efficacy, survival units of the mice bearing

tumor, as well as the systemic toxicity assay demonstrated the efficiency of

cooperative tumor targeting diagnosis and controlled NO-releasing chemotherapy. To

the best of our knowledge, this is the first time of the external magnet and HA-FA

actively induced synergistic effect tumor targeting systems based on NO

chemotherapy in vivo, serving as a new theranostic system.