作者：Qianyu Zhang, Li Wang, Yajun Jiang, Wei Gao, Yinsong Wang, Xiaoying Yang*, Xinlin Yang, Zunfeng Liu*
关键字：gold nanorods, photothermal therapy, drug delivery, gene delivery
论文来源：期刊
具体来源：Adv. Mater. Interfaces 2017, 1701166 (1-9). DOI: 10.1002/admi.201701166.
发表时间：2017年

The multifunctional nanocomposites with grafting polyamidoamine (PAMAM) dendrimers

up to third generation (G3) was grown onto the surface of mesoporous silica-coated gold nanorods (AuNRs@SiO2) via a divergent technique. The resultant AuNRs@SiO2-G3

nanocomposites with uniform size and excellent stability not only enable their utilization as targeted contrast agents for photothermal cancer therapy, but also serve as scaffolds for the intracellular delivery of anti-cancer drug and small interfering RNA (siRNA) to enhance the efficiency of cancer therapy. The controlled doxorubicin (DOX) release from AuNRs@SiO2-G3 nanocomposites is significantly improved under lower pH condition and near-infrared (NIR) laser irradiation. The Bcl-2 targeted siRNA is transfected into tumor

cells and induce knockdown of the protein expression, which is confirmed by western blot assays. Furthermore, the complementary effect of chemo-and gene therapy to MCF-7 cells for improved photothermal therapy is demonstrated by MTT assay. The DOX and siRNA co-loaded AuNRs@SiO2-G3 nanocomposites showed much lower cytotoxicity compared to the DOX, relsuting in low toxicity to nomal tissues. The multifunctional nanocomposites have potential application as nanoplatforms to integrate the photothermal-chemo-gene tumor therapy with high efficiency.