作者：Tuanwei Liu, Jingjing Hu, X. Y. Ma, B. Kong, Jilan Wang, Zhide Zhang,* Dianshun Guo,* Xinlin Yang*
关键字：NO vehichle; tumor targeted delivery, S-nitrosothiol, Polymer microsphere
论文来源：期刊
具体来源：J Mater Chem B, 5 (36), 7519-7528 (2017). DOI: 10.1039/C7TB01715D
发表时间：2017年

Tumor targeted hollow double-layered polymer nanoparticle (HDPNs) with S-nitrosothiols for nitric mono-oxide (NO)-releasing as chemotherapy is described. Via a two-stage distillation precipitation co-polymerization, simple post-treatment and S-nitrosothiols modification, the S-nitroso HDPNs showed a pH and glucose dual responsiveness,

which is benefit for the accurate binding with the sialic acid over-expressed

cancer cells, providing prerequisites for the disulfide polymer assisted cell

taken-up, intracellular GSH induced decomposition and rapid NO release.

Confocal microscope and cytotoxicity assay with normal versus tumor cells

demonstrated the in vitro recognition, intracellular delivery ability and tumor cell targeting

cytotoxicity. Especially worth mentioning, the inevitable small amount of NO

leakage in the transmission will take part in normal physiological activities

and not cause serious side effects, providing a possible solution to avoid the

intolerable side effects of the traditional chemotherapy treatment for cancer.