作者：Wu, Zhengfang; Wang, Dehui; Yang, Peng
关键字：Surface， Photograft，Polymer Brush，Bioinert，Bioactive
论文来源：期刊
具体来源：Industrial & Engineering Chemistry Research
发表时间：2014年
Organic polymeric materials would exploit excellent potential in biomedical field if their interfacial problem could be fully resolved. A necessary prerequisite to this purpose often involves in the simple but effective synthesis of bioactive surface to endow polymer surfaces with high reactivity towards efficient biomolecules conjugation and bioinert surface to prevent non-specific adsorption of non-target biomolecules. Although the corresponding research has been an important topic, actually few strategy could pave the way to comprehensively and simply tackle both of bioactive and bioinert surfaces preparation issues. Herein we reported an extremely simple and integrative bifunctional method that could efficiently tailor organic material surface towards both of bioactive and bioinert functions. This method is based on the use of amides-initiated photochemical reaction in a confined space, which depending on the type of solutes used, results in the incorporation of primary amine groups or surface carbon radicals on inert polymer surface. The grafted amine group could be used as highly reactive site for biomolecule conjugation and the surface carbon radical could be used to initiate radical graft polymerization of anti-fouling polymer brushes. We expect this simple but powerful method could provide a general resolution to solve the interfacial problem of organic substrate, offering a low-cost practical approach for real biomedical applications.