writer：Chen Li, Danyang Lu, Jingjing Deng, Xu Zhang*, Peng Yang*
keywords：Amyloid-like assembly, surface modification, antifouling, dental hypersensitivity
source：期刊
specific source：Advanced Materials
Issue time：2019年

Exposure of dentin tubules (DTs) leads to the transmission of external stimuli within the DTs, which causes dental hypersensitivity (DH). To date, a variety of products have been developed for occluding DTs. However, clinical strategies have not achieved satisfactory treatment because most desensitizers that are commercially available or in development are only able to seal the orifices, rather than the deep regions of DTs, thus lacking long-term stability. Herein, we show that the fast amyloid-like aggregation of lysozyme conjugated with polyethylene glycol (PEG) (lyso-PEG) can afford a robust ultrathin nanofilm on the deep walls of DTs through a rapid one-step aqueous coating process (in 2 min). The resultant nanofilm provides a highly effective antifouling platform for resisting the attachment of oral bacteria such as S. mutans and induces remineralization in the DTs to seal both the orifices and depths of DTs by forming hydroxyapatite (HAp) minerals in situ. Both in vitro and in vivo animal experiments prove that the nanofilm-coated dentins are occluded with a depth of over 60 ± 5 μm, which is at least 6 times deeper than that reported in the literature. This approach thus demonstrates the concept that an amyloid-like proteinaceous nanofilm can offer an inexpensive, rapid and efficient therapy for treating DH with the potential of long-term stability.

DOI:10.1002/adma.201903973; Article accepted on 2 August, 2019