writer：Wang, L.; Huang, S.; Wang, M.; Liu, Z.; Chen, X.; Yang, H.*
keywords：nucleoside
source：期刊
specific source：Macromolecules, 2021, 54, 341-350.
Issue time：2021年

In recent years, the synthesis and self-assembly studies of artificial nucleic acids have drawn tremendous scientific

attention and interest. In this manuscript, we report a strategy for synthesizing double-stranded alternating heterodinucleoside

polytriazoles through the 1,4-regioregular copper(I)-catalyzed [3+2] azide?alkyne cycloaddition polymerization of the

complementary hydrogen-bonded, sequence-embedded, azide/alkyne-functionalized heterodinucleoside monomeric complexes.

The distinct self-assembly behaviors between the heterodinucleoside polytriazoles and their monomeric precursors indicate that the

1,4-regioregular polytriazole backbone can not only constrain and regularize the complementary hydrogen bonds of the nucleobases

but also transfer the molecular chirality of monomers into the supramolecular assemblies to induce the formation of helical

nanofibers. We believe that this approach can be further extended to the iterative polymerization of nucleoside monomers with more

complex nucleobase sequences for developing novel artificial nucleic acids.