writer：Wang, L.; Wang, M.; Guo, L.; Sun, Y.; Zhang, X.; Lin, B.; Yang, H.*
keywords：DNA
source：期刊
specific source：Macromolecules, 2019, 52, 649-659.
Issue time：2019年

The synthesis and

self-assembly studies of DNA/RNA-mimic artificial polymers have

drawn extensive scientific attention, since synthetic chemists can manipulate

the functions of these modified nucleic acid molecules by varying their

macromolecular backbone and nucleoside unit structures. In this manuscript, we

report two types of modified nucleic acids with olefin bridges prepared by

acyclic diene metathesis polymerization (ADMET). The 3’-OH and 5’-OH groups of

deoxythymidine and deoxyadenosine analogue monomers are functionalized with

either two terminal allyl units or allyl and acryloyl units respectively. The consequent

ADMET approaches provide either regio-uncontrolled oligodeoxynucleosides with

poor E/Z selectivity or well-defined oligodeoxynucleosides built in a

highly ordered head-to-tail addition manner. These two different

macromolecular structures markedly influence the self-assembly morphologies of

the corresponding oligodeoxynucleosides, which show spherical and filamentous helix

nanostructures respectively.