writer：Ahmed Mohammed Elamin Abdalla , Lin Xiao , Chenxi Ouyang and Guang Yang*
keywords：Engineered nanoparticles, thrombosis , cancer
source：期刊
specific source：Nanoscale，2014，6(23): 14141-14152
Issue time：2014年

Abstract: Engineered nanoparticles are being increasingly produced for specific applications in medicine. Broad selections of nano-sized constructs have been developed for applications in diagnosis, imaging, and drug delivery. Nanoparticles as contrast agents enable conjugation with molecular markers which are essential for designing effective diagnostic and therapeutic strategies. Such investigations can also lead to a better understanding of disease mechanisms such as cancer-associated thrombosis which remains unpredictable with serious bleeding complications and high risk of death. Here we review the recent and current applications of engineered nanoparticles in diagnosis and therapeutic strategies, noting their toxicity in relation to specific markers as a target.