writer：Shanshan Zang, Qi Zhuo, Xiao Chang, Guixing Qiu, Zhihong Wu*, Guang Yang*
keywords：Bacterial cellulose, Human adipose-derived stem cells, Bone tissue engineering, Biomaterials, Artificial scaffold
source：期刊
specific source：Carbohydrate Polymers,2014, 104: 158-165.
Issue time：2014年

Abstract: Bacterial  cellulose  (BC)  has  been  proposed  as  a  biomaterial  applied  in  biomedical  scope  due  to  its  good biocompatibility.  Recent  reports  showed  that  human  adipose-derived  stem  cells  (HASCs)  have  become  a new  choice  to  be  used  as  seeding  cells  in  tissue  engineering.  The  objective  of  this  study  is  to  explore  the potential  of  using  BC  and  HASCs  as  scaffold  and  seeding  cells  in  bone  tissue  engineering.  The  osteogenic differentiation  was  investigated  by  Von  Kossa,  Alizarin  Red,  ALP  cellular  staining  and  RT-PCR.  The  results showed  that  HASCs  took  a  successful  osteogenic  differentiation  on  BC.  Moreover,  the  in  vivo  animal  test also  provided  the  confirmation  of  the  repair  ability  of  BC  on  damaged  bone.  In  conclusion,  the  author demonstrates  the  osteogenic  differentiation  of  HASCs  on  BC  and  the  feasibility  of  using  BC  and  HASCs  as scaffold  and  seeding  cells  in  bone  tissue  engineering.