A transparent wound dressing based on bacterial cellulose whiskerand poly(2-hydroxyethyl methacrylate)
writer：Zeng Dia,b,1, Zhijun Shia,b,1, Muhammad Wajid Ullaha,b, Sixiang Lia,b, Guang Yanga,b,.
keywords：BC whisker、Hydrogel、Antibacterial properties,Transparent wound dressing
source：期刊
specific source：Biological Macromolecules
Issue time：2017年
The current study was aimed to develop a transparent wound dressing comprised of bacterial cellulose(BC) and poly (2-hydroxyethyl methacrylate) (PHEMA) hydrogel coated with silver (Ag) nanoparticles.Briefly, different concentrations of BC whiskers (BCWs) were added into the HEMA solution to formPHEMA/BCWs hydrogel with volume ratio of monomer HEMA and BCWs as 7:3 and 1:1. The addition ofBCWs into PHEMA matrix improved its equilibrium water content and light transmittance about 20%-40%and 10%, respectively. The Young’s modulus for PHEMA was found to be 0.72 MPa, which was improvedto 0.57 MPa and 0.50 MPa for PHEMA/BCWs 7:3 and PHEMA/BCWs 1:1, respectively. Further, immersionof PHEMA/BCWs hydrogel in the AgNO3and NaBH4solutions bestowed it with antibacterial property andproduced inhibition zones of 0.5 ± 0.15 cm and 0.25 ± 0.15 cm against Escherichia coli and Staphylococcusaureus, respectively. Similarly, PHEMA/BCWs prepared with 0.001 M AgNO3and 0.001 M NaBH4solutionsshowed 99% and 90% reduction in colony forming unit (CFU) for E. coli and S. aureus, respectively, after 24 h.The PHEMA/BCWs/Ag hydrogel facilitated the growth of NIH3T3 fibroblast, showing their low toxicity.These results demonstrate the suitability of PHEMA/BCWs/Ag hydrogel for its application as potentialtransparent wound dressing material for skin repair.