Associate Professor Won Jong Kim from Pohang University of Science and Technology invited by professor Yang Guang, visited Huazhong University of Science and Technology (HUST) from May 28 to 31, 2012. He gave an excellent lecture entitled Biopolymer-based gene carriers for gene delivery and silencing. Prof. Kim obtained his Doctor degree at Department of Biomolecular Engineering, Tokyo Institute of Technology. He visited Center for Controlled Chemical Delivery, University of Utah, as postdoctoral fellow. Since August 2007, Doctor Kim has served as assistant professor and associate professor at Department of Chemistry. His main interests are Non-viral polymeric Gene Carriers，siRNA gene therapy，SNP detection，Nanomachine by DNA/polymer complex and Nitric Oxide delivery. 64 papers have been published on many famous and high IF journals, such as, Nature Material 1, Biomaterials 9, Journal of Controlled Release 10, Accounts of Chemical Research 1, and so on. Abstract: Gene therapy has attracted enormous attention over the past few decades due to its immense potential as a therapeutic tool for combating various genetic disorders. Among two kinds of vectors that are employed till date, viral vectors exhibit higher transfection efficiencies, but their use is impaired greatly due to the associated toxicity, immunogenicity, and non-viable scale up procedures. As a result, tremendous impetus has been directed toward the development of various nonviral synthetic delivery systems which could be safer and more efficient. A number of cationic polymers including polyethylenimine (PEI), chitosan, and poly(L-lysine) have also been reported to exhibit efficient gene transfection. However, the induced cytotoxicity and non-biodegradability of these cationic polymeric vectors along with inefficient release of gene from the polymeric complexes inside the cell, lack of target specificity impede the prevalent practical realization of gene therapy. Therefore, in our quest to develop a highly coveted vector which could provide all these attributes, we have devised several highly efficient vector systems. Our approaches are focused mainly on the development of smart nanoparticles which could exploit the intracellular and extracellular features of the target cells by imparting several structural or functional traits into the nanoconstructs in order to overcome various impediments.