writer：Jingjing Huang, Dong Wang,* Ying Lu, Mufang Li and Weilin Xu
keywords：Surface zwitterionically，click chemistry
source：期刊
Issue time：2013年
Antifouling nanofibers with zwitterionic materials on surfaces that can prevent the nonspecific adhesion of
biomolecules and microorganism are in demand for high efficiency biosensors and affinity membranes. The
functionalization of zwitterionic sulfobetaine on surfaces of PVA-co-PE nanofiber membrane via click
chemistry is performed employing two synthesis routes and reported in this paper. PVA-co-PE nanofiber
membranes were activated with cyanuric chloride, and then surface functionalized with sodium azide or 2-
propynylamine to prepare “clickable” nanofibers with azide or alkynyl groups, respectively. The zwitterionic
sulfobetaine was finally “clicked” onto PVA-co-PE nanofiber membranes. The successful surface
functionalizations of PVA-co-PE nanofiber membrane were confirmed with FTIR-ATR, Raman spectroscopy,
XPS and EDS. The analysis of element composition using XPS indicated that alkynylation of activated PVAco-
PE nanofiber membranes can “click” more sulfobetaines on nanofiber surfaces than surface azidation.
SEM results showed that functionalized PVA-co-PE nanofiber membranes maintained well-defined
nanofibrous morphology. PVA-co-PE nanofiber membranes with zwitterionic sulfobetaine demonstrated
excellent antifouling performance by effectively resisting bovine serum albumin (BSA) protein