作者：Yuqin Wang ，Yingying Jin ， Wei Chen , Jingjie Wang , Hao Chen , Lin Sun ，Xi Li， Jian Ji , Qian Yu , Liyan Shen , Bailiang Wang
关键字：Drug-resistant bacteria,Bacterial biofilms,Photothermal therapy,Photodynamic therapy,Targeting
论文来源：期刊
发表时间：2018年

The spread of resistant bacteria and the development bacterial biofilm have been two major challenges in the application of biomaterials, causing device failure as well as tissue infections. The overuse of antibiotics has become a common cause of the emergence of multiple antibiotics-resistant bacteria. Besides, biofilm infections are notoriously difficult to treat, as the biofilm matrix provides physical protection from antibiotic treatment. Recently, nanomaterials with high drug loading capacity, various types of stimuli responsiveness, smart targeting and small-size are able to increase local drug concentration and to escape the capture of macrophages.Especially, the loading of drugs to the nanomaterials enhances chances for macrophage capture which is aserious problem related to interaction with immune system. Phototherapy including photothermal therapy and photodynamic therapy has attracted wide attentions in treating infectious diseases as the development of drug-resistant bacteria and bacterial biofilms. In addition, based on the special microenvironment of bacterial infections, various construction and modification methods of nanomaterials showed high efficient antibacterial properties. This review describes the latest advances in the phototherapy strategies to resist resistant bacteria and biofilms related infections.