Photo-controlled host–guest interaction as a new strategy toimprove the preparation of “breathing” hollow polymernanospheres as controlled drug delivery

Haitao Zhang, Wei Tian,* RongtianSuo, Yang Yue, Xiaodong Fan, Zhen Yang, Hui Li, Wanbin Zhang,and Yang Bai

This paper presents the photo-controlled host–guest interaction between azobenzene and β-cyclodextrin as a newstrategy to improve the method for core removal to prepare poly((itaconoyloxy)ethylmethacrylate)-block-poly(Nisopropylacrylamide-based hollownanospheres. This improved method for the preparation of hollow nanospheres issimple,environment friendly, and highly efficient. The resulting hollow nanospheres displayed a typical“breathing”behavior, which further induces the controlled release of doxorubicin hydrochloride. Cellular toxicity evaluation indicated that the hollow nanospheres possess good biocompatibility and can be used as a promising doxorubicinhydrochloride carrier.

全文链接：http://pubs.rsc.org/en/content/articlelanding/2014/TB/C5TB01665G#!divAbstract