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课题组在Macromolecular Bioscience发表研究成果!


全文链接:http://onlinelibrary.wiley.com/doi/10.1002/mabi.201400395/abstract

Keywords:

  • acid-labile;
  • drug delivery;
  • micelles;
  • ortho ester

  The diblock copolymer, PEG-b-PMEA, was synthesized by reversible-addition fragmentation chain transfer polymerization (RAFT). The PMEA block contained a polymethacrylamide backbone and twin ortho ester rings in the side-chains. At neutral pH, PEG-b-PMEA self-assembled to form stable micelles. At pH 5, the twin ortho ester rings were quickly hydrolyzed to completion in 12?h, and releasing nearly 70% of the encapsulated Nile Red dye. The PEG-b-PMEA micelles were completely nontoxic to cultured cells as determined by the MTT assay. Paclitaxel (PTX)-loaded micelles showed toxicity toward lung cancer cells comparable to that of the free PTX at equivalent doses. These results suggest that the PEG-b-PMEA micelles could be useful nano-carriers for pH-responsive delivery of poorly soluble anticancer drugs.