Heterogeneous Structure and Miscibility of Phenylboronic Acid-Rich Chitosan Nanoparticles as Revealed by Advanced Solid-State NMR
writer：Fenfen Wang, Tiehong Chen, Pingchuan Sun*
keywords：solid-state NMR, heterogeneous structure, miscibility, nanoparticles, chitosan
source：期刊
specific source：Chinese Journal of Magnetic Resonance 2015, 32, 354-362.
Issue time：2015年
By using advanced solid-state NMR techniques, the heterogeneous structure and inter-polymer miscibility of chitosan-poly (N-3-acrylamidophenyl-boronic acid) nanoparticles
(CS-PAPBA NPs) were investigated. The 13C CPMAS experiments indicate the conformational
change of chitosan when incorporated with phenyl boronic acid. Two-dimensional (2D) 13C-1H HETCOR experiments further demonstrate that a portion of chitosan is closely bound with PAPBA in the interphase by means of boronic coordination interaction. 2D 1H-1H spin-exchange with spin-diffusion experiments demonstrate that the interfacial mixing of chitosan and PAPBA, and micro-phase separation is of the order of 15–20 nanometers.