writer：Zhang Y, Cui L, Che X, Zhang H, Shi N, Li C, Chen Y, Kong W
keywords：Zein;Film,Coating,Controlled delivery,Biomedical application
source：期刊
specific source：J Control Release. 2015, 206: 206-219.(SCI,IF=7.441)
Issue time：2015年

Zein is a class of alcohol-soluble prolamine proteins present inmaize endosperm, which was approved as a generally recognized as safe (GRAS) excipient in 1985 by the United States Food and Drug Administration (US-FDA) for film coating of pharmaceuticals, e.g., tablets. Despite its long-term application in tablet production, effects of zein coating on tablet properties are still not fully understood.Moreover,many studies have also been conducted

to illustrate its potential as an active ingredient of direct compressed tablets and film-based delivery carriers. In addition, the use of zein as a functional film coatingmaterial for newbiomedical applicationswas alsowidely investigated in recent reports,which involvedmedical devices, nanoparticles, quantumdots and nanofibers. In this review, the present status of zein in the form of a thin film and uniform layer for use as a biomedical material is discussed. In addition, studies related to the behaviors and properties of zein films are also summarized and analyzed based on publishedworks to gainmechanistic insights into the relationship between zein film and various improved profiles. This reviewwill benefit future prospects of the use of zein film in drug delivery and biomedical applications.