作者：Xian Liu,Shaobing Zhou*, et al.
关键字：Shape memory, scaffold, tissue engineering, drug controlled release
论文来源：期刊
具体来源：Biomacromolecules, 2014,15, 1019-1030.
发表时间：2014年
 Implantation  of  a  porous  sca ff old  with  a  large
volume into the body in a convenient and safe manner is still a
challenging task in the repair of bone defects. In this study, we
present  a  porous  smart  nanocomposite  sca ff old  with  a
combination of shape memory function and controlled delivery
of  growth  factors.  The  shape  memory  function  enables  the
sca ff old with a large volume to be deformed into its temporal
architecture with a small volume using hot-compression and can
subsequently recover its original shape upon exposure to body
temperature  after  it  is  implanted  in  the  body.  The  sca ff old
consists of chemically cross-linked poly(ε-caprolactone) (c-PCL)
and  hydroxyapatite  nanoparticles.  The  highly  interconnected
pores  of  the  sca ff old  were  obtained  using  the  sugar  leaching
method. The shape memory porous sca ff old loaded with bone
morphogenetic protein-2 (BMP-2) was also fabricated by coating the calcium alginate layer and BMP-2 on the surface of the
pore wall. Under both in vitro and in vivo environmental conditions, the porous sca ff old displays good shape memory recovery
from the compressed shape with deformed pores of 33 μm in diameter to recover its porous shape with original pores of 160 μm
in diameter. In vitro cytotoxicity based on the MTT test revealed that the sca ff old exhibited good cytocompatibility. The in vivo
micro-CT and histomorphometry results demonstrated that the porous sca ff old could promote new bone generation in the
rabbit mandibular bone defect. Thus, our results indicated that this shape memory porous sca ff old demonstrated great potential
for application in bone regenerative medicine.