当前位置:群英聚首 > 论文著作 > 正文
A three-dimensional printable conductive composite dressing for accelerating wound healing under electrical stimulation
来源:江国华教授个人网站 发布日期:2024-10-16
作者:Xinxiang Chai, Yanzhen Lou, Lei Nie Amin Shavandi, Khaydar E. Yunusov, Yanfang Sun, Guohua Jiang*
关键字:conductive dressings, 3D printing, electrical stimulation, wound healing
论文来源:期刊
具体来源:Colloids and Surfaces B: Biointerfaces
发表时间:2024年

Abstract: In this study, a bioink based on poly(vinyl alcohol) (PVA) and k-carrageenan network was prepared using conductive polymer (PEDOT:PSS) as conducting medium, and (+)-Catechin-loaded mesoporous ZnO (CmZnO) as antibacterial and anti-inflammatory active medium. 3D conductive composite dressing was further fabricated by an extrusion 3D printing technology. Our results showed that the as-obtained composite dressing had suitable conductivity, efficient blood clotting capacity, and good adhesiveness. It also showed that the as-fabricated conductive composite had 92.9% and 95.6% antibacterial activity against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), respectively. Furthermore, the conductive dressing with an optimal electrical stimulation (ES) parameter showed in vivo blood clotting capacity, and it enhanced in vivo wound healing process in a full-thickness skin defect model than commercial dressings by upregulating the gene expression of growth factors including CD-31 and downregulating inflammatory factor expression of IL-6.

Keywords: conductive dressings, 3D printing, electrical stimulation, wound healing

Copyright © 2005 Polymer.cn All rights reserved
中国聚合物网 版权所有
经营性网站备案信息

京公网安备11010502032929号

工商备案公示信息

京ICP证050801号

京ICP备12003651号